caa a22 4500 606186328 CHVBK 20210128100835.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00405-014-3144-x doi (NATIONALLICENCE)springer-10.1007/s00405-014-3144-x A review of the management and prognosis of thyroid carcinoma with tracheal invasion [Elektronische Daten] [Anquan Peng, Youzhong Li, Xinming Yang, Zian Xiao, Qingla Tang, Qin Wang] The objective of the study was to explore the surgical approaches, treatment significance and prognosis of thyroid carcinoma with tracheal invasion. We retrospectively reviewed 48 patients with tracheal invasion by papillary thyroid carcinoma, follicular thyroid carcinoma and medullary thyroid carcinoma by means of clinical data ranging from 1993 to 2011. The patients were classified into three groups in terms of the depth and extent of tracheal invasion by the tumors, i.e., group A of 18 patients with localized tracheal invasion; group B of 21 patients with intraluminal tracheal invasion, and group C of nine patients with extensive invasion of the trachea, larynx, esophagus and/or mediastinum. Of these patients, 18 received radical tumorectomy and segmental resection of the outer layer of the tracheal wall; 21 had radical tumorectomy, circumferential sleeve trachea resection or segmental tracheal resection plus tracheal repair, and the remaining nine patients underwent radical tumorectomy, segmental trachea resection and esophagolaryngectomy. 46 patients took I131 oral solution and/or had external radiotherapy postoperatively. A survival analysis was done using Kaplan-Meier Estimator for cumulative survival probability together with Log-Rank test, and Cox Regression Model was used for multivariate analysis. (1) In group A of 18 patients, 10 took I131oral solution and 7 received radiotherapy after surgery. The overall 5 and 10-year survival rates were 88.93 and 77.78%, respectively; (2) In group B of 21 patients, 15 took I131 oral solution and 7 received radiotherapy after surgery. The overall 5 and 10-year survival rates were 90.47 and 61.87%, respectively; (3) In group C of 9 patients, 7 received radiotherapy after surgery. The overall 5 and 10-year survival rates were 77.78 and 22.22%, respectively. Whether they received postsurgical I131 treatment or radiotherapy, there was a statistical difference between the 5-year survival rates and the 10-year survival rates in all of these three groups (P value in each group is <0.05). In the treatment of thyroid carcinoma with tracheal invasion, radical tumorectomy plus tracheal repair, segmental tracheal resection or circumferential sleeve trachea resection could lengthen the survival time. Radical tumorectomy could enhance the probability of survival of patients with thyroid carcinoma that had extensively invaded the larynx, esophagus and/or mediastinum. Postsurgical I131 treatment and radiotherapy enhanced the probability of survival. Springer-Verlag Berlin Heidelberg, 2014 Thyroid carcinoma nationallicence Trachea nationallicence Surgery nationallicence I131 treatment nationallicence Radiotherapy nationallicence Peng Anquan Department of Otorhinolaryngology, Head and Neck Surgery, The Second Xiangya Hospital of Central South University, 139 Renmin Road, 410011, Changsha, China aut Li Youzhong Department of Otorhinolaryngology, Head and Neck Surgery, The Second Xiangya Hospital of Central South University, 139 Renmin Road, 410011, Changsha, China aut Yang Xinming Department of Otorhinolaryngology, Head and Neck Surgery, The Second Xiangya Hospital of Central South University, 139 Renmin Road, 410011, Changsha, China aut Xiao Zian Department of Otorhinolaryngology, Head and Neck Surgery, The Second Xiangya Hospital of Central South University, 139 Renmin Road, 410011, Changsha, China aut Tang Qingla Department of Otorhinolaryngology, Head and Neck Surgery, The Second Xiangya Hospital of Central South University, 139 Renmin Road, 410011, Changsha, China aut Wang Qin Department of Otorhinolaryngology, Head and Neck Surgery, The Second Xiangya Hospital of Central South University, 139 Renmin Road, 410011, Changsha, China aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/8(2015-08-01), 1833-1843 0937-4477 272:8<1833 2015 272 405 https://doi.org/10.1007/s00405-014-3144-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3144-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Peng Anquan Department of Otorhinolaryngology, Head and Neck Surgery, The Second Xiangya Hospital of Central South University, 139 Renmin Road, 410011, Changsha, China aut NATIONALLICENCE 700 1- Li Youzhong Department of Otorhinolaryngology, Head and Neck Surgery, The Second Xiangya Hospital of Central South University, 139 Renmin Road, 410011, Changsha, China aut NATIONALLICENCE 700 1- Yang Xinming Department of Otorhinolaryngology, Head and Neck Surgery, The Second Xiangya Hospital of Central South University, 139 Renmin Road, 410011, Changsha, China aut NATIONALLICENCE 700 1- Xiao Zian Department of Otorhinolaryngology, Head and Neck Surgery, The Second Xiangya Hospital of Central South University, 139 Renmin Road, 410011, Changsha, China aut NATIONALLICENCE 700 1- Tang Qingla Department of Otorhinolaryngology, Head and Neck Surgery, The Second Xiangya Hospital of Central South University, 139 Renmin Road, 410011, Changsha, China aut NATIONALLICENCE 700 1- Wang Qin Department of Otorhinolaryngology, Head and Neck Surgery, The Second Xiangya Hospital of Central South University, 139 Renmin Road, 410011, Changsha, China aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/8(2015-08-01), 1833-1843 0937-4477 272:8<1833 2015 272 405