caa a22 4500 606186336 CHVBK 20210128100835.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00405-015-3611-z doi (NATIONALLICENCE)springer-10.1007/s00405-015-3611-z Glottic and supraglottic pT3 squamous cell carcinoma: outcomes with transoral laser microsurgery [Elektronische Daten] [Dimitrios Pantazis, Georgia Liapi, Dimitrios Kostarelos, Georgios Kyriazis, Theodoros-Leonidas Pantazis, Maria Riga] Patients diagnosed with T3 squamous cell laryngeal carcinomas are nowadays offered either organ-preserving surgical or non-surgical treatment, with the optimum approach remaining undefined. No direct comparison of organ-preserving therapeutical options, stratified by anatomical subsites is available in the literature. The aim of this study is to present institutional treatment outcomes for laser-assisted microsurgery (TLM) of laryngeal T3 squamous cell carcinomas and review the relevant literature. Sixty-four consecutive, previously untreated patients were evaluated. Twenty-four supraglottic and 19 glottic patients were treated with TLM and neck dissection, tumor exposure and postoperative upstaging of the tumors through pathology evaluation of the specimens being the only exclusion criteria. Five-year disease-specific survival and organ preservation rates for supraglottic carcinomas were both 91.7%. The respective values for glottic carcinomas were 63.2 and 73.3%. TLM-treated T3 supraglottic tumors seem to attribute better outcomes than T3 glottic tumors in terms of recurrence-free survival, organ preservation and local control (p=0.01, <0.0001 and 0.01, respectively). The results of this study suggest that TLM-treated T3 supraglottic tumors have a good prognosis, substantially better than that of glottic tumors. A literature review, on the other hand, attributes to chemo-radiation-treated T3 supraglottic tumors a considerably poorer prognosis. Further studies of homogenous populations in terms of anatomical subsites are needed in order to reach a consensus regarding treatment of T3 laryngeal tumors. Springer-Verlag Berlin Heidelberg, 2015 Supraglottic nationallicence Glottic nationallicence Squamous cell nationallicence Carcinoma nationallicence Transoral laser microsurgery nationallicence Organ preservation nationallicence Pantazis Dimitrios ENT Department, "Thriasion” Hospital of Athens, Athens, Greece aut Liapi Georgia Pathology Laboratory, "Thriasion” Hospital of Athens, Athens, Greece aut Kostarelos Dimitrios ENT Department, "Thriasion” Hospital of Athens, Athens, Greece aut Kyriazis Georgios ENT Department, "Thriasion” Hospital of Athens, Athens, Greece aut Pantazis Theodoros-Leonidas ENT Department, "Thriasion” Hospital of Athens, Athens, Greece aut Riga Maria Democritus University of Thrace, Palagia, PO Box 2206, 68100, Alexandroupolis, Greece aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/8(2015-08-01), 1983-1990 0937-4477 272:8<1983 2015 272 405 https://doi.org/10.1007/s00405-015-3611-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-015-3611-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pantazis Dimitrios ENT Department, "Thriasion” Hospital of Athens, Athens, Greece aut NATIONALLICENCE 700 1- Liapi Georgia Pathology Laboratory, "Thriasion” Hospital of Athens, Athens, Greece aut NATIONALLICENCE 700 1- Kostarelos Dimitrios ENT Department, "Thriasion” Hospital of Athens, Athens, Greece aut NATIONALLICENCE 700 1- Kyriazis Georgios ENT Department, "Thriasion” Hospital of Athens, Athens, Greece aut NATIONALLICENCE 700 1- Pantazis Theodoros-Leonidas ENT Department, "Thriasion” Hospital of Athens, Athens, Greece aut NATIONALLICENCE 700 1- Riga Maria Democritus University of Thrace, Palagia, PO Box 2206, 68100, Alexandroupolis, Greece aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/8(2015-08-01), 1983-1990 0937-4477 272:8<1983 2015 272 405