caa a22 4500 606186344 CHVBK 20210128100835.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00405-014-3265-2 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3265-2 Adenocarcinomas of the sinonasal tract: a case series from an Oncology Centre in Northern Portugal [Elektronische Daten] [R. Veloso-Teles, I. Ribeiro, J. Castro-Silva, E. Monteiro] Sinonasal malignant neoplasms are rare and adenocarcinomas account for 10-20% of these cancers. Our aim is to characterise the clinical presentation, risk factors and outcomes of patients with adenocarcinoma treated at our institution. Retrospective review of medical records of patients with sinonasal adenocarcinomas, treated at IPO-Porto from January 2008 until December 2012. Twenty-eight patients with adenocarcinomas were selected from a total of 53 patients with sinonasal cancers. There was a male predominance (93%), a mean age at diagnosis of 56years and a rate of occupational wood dust exposure of 71%. The most common treatment option was surgery followed by adjuvant radiotherapy. The 5year disease-free and cancer-specific survival was 58 and 60%, respectively. The following factors had negative impact on disease-free survival: advanced AJCC stage (p=0.014); skull base invasion (p=0.002); poorly differentiated or mucinous subtypes histology (p=0.034) and imaging findings of residual tumour before adjuvant radiotherapy (p<0.001). Endoscopic tumour resection was not associated with adverse outcomes. The role of volume-modulated arch therapy in the treatment of sinonasal tumours has to be clarified. The higher rate of adenocarcinomas among sinonasal cancers in this series comparing with previous reports, even from our institution, suggests that this pathology is rising in Northern Portugal. Despite substantial local failure, sinonasal adenocarcinomas have a relatively favourable prognosis in terms of cancer-specific survival. Springer-Verlag Berlin Heidelberg, 2014 Nasal cancer nationallicence Paranasal sinus cancer nationallicence Adenocarcinoma nationallicence Veloso-Teles R. Department of Otorhinolaryngology, Alto Ave Hospital Centre (CHAA), Rua dos Cutileiros, Creixomil, 4835-044, Guimarães, Portugal aut Ribeiro I. Department of Radiotherapy, Portuguese Institute of Oncology in Porto (IPO-Porto), Porto, Portugal aut Castro-Silva J. Department of Otorhinolaryngology, Portuguese Institute of Oncology in Porto (IPO-Porto), Porto, Portugal aut Monteiro E. Department of Otorhinolaryngology, Portuguese Institute of Oncology in Porto (IPO-Porto), Porto, Portugal aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/8(2015-08-01), 1913-1921 0937-4477 272:8<1913 2015 272 405 https://doi.org/10.1007/s00405-014-3265-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3265-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Veloso-Teles R. Department of Otorhinolaryngology, Alto Ave Hospital Centre (CHAA), Rua dos Cutileiros, Creixomil, 4835-044, Guimarães, Portugal aut NATIONALLICENCE 700 1- Ribeiro I. Department of Radiotherapy, Portuguese Institute of Oncology in Porto (IPO-Porto), Porto, Portugal aut NATIONALLICENCE 700 1- Castro-Silva J. Department of Otorhinolaryngology, Portuguese Institute of Oncology in Porto (IPO-Porto), Porto, Portugal aut NATIONALLICENCE 700 1- Monteiro E. Department of Otorhinolaryngology, Portuguese Institute of Oncology in Porto (IPO-Porto), Porto, Portugal aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/8(2015-08-01), 1913-1921 0937-4477 272:8<1913 2015 272 405