caa a22 4500 606186530 CHVBK 20210128100836.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00405-014-3065-8 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3065-8 Lipomatous tumours of the head and neck: a spectrum of biological behaviour [Elektronische Daten] [Eelco de Bree, Alexander Karatzanis, Jennifer Hunt, Primož Strojan, Alessandra Rinaldo, Robert Takes, Alfio Ferlito, Remco de Bree] Lipomatous tumours are rare in the head and neck region. Their biological behaviour varies greatly, from absolutely benign to histologically benign but locally infiltrative and, finally, invasive with metastatic potential. Each lipomatous tumour has to be treated accordingly. It is of paramount importance before eventual surgery is planned to perform adequate imaging, diagnostic biopsy and careful assessment. Only in small (<5cm), superficial soft tissue tumours or when magnetic resonance imaging has demonstrated specific features of lipoma, may diagnostic biopsy be omitted. In these cases, expectant management or simple excision is appropriate. Adequate preoperative diagnosis is important to assure adequate tumour control as well as optimal functional and cosmetic outcome. The major problem in the treatment of lipomatous tumours of the head and neck region is the presence of nearby delicate structures. Especially, wide surgical excision of liposarcomas may be hindered by anatomic constraints and may result in impaired functional and cosmetic outcome. Neoadjuvant radiotherapy and specific systemic chemotherapy may be helpful in the treatment of liposarcoma, especially when unresectable or when primary surgery is expected to result in poor oncological, functional or cosmetic outcome. Greater emphasis placed on the underlying biology of individual sarcoma subtypes, development and evaluation of novel therapies and greater specificity in the selection of chemotherapy agents based on activity in individual histological subtypes are expected to lead to improved efficacy of systemic treatment. Springer-Verlag Berlin Heidelberg, 2014 Lipomatous tumour nationallicence Head and neck nationallicence Lipoma nationallicence Lipoma variants nationallicence Liposarcoma nationallicence de Bree Eelco Department of Surgical Oncology, Medical School of Crete University Hospital, Heraklion, Greece aut Karatzanis Alexander Department of Otolaryngology, Medical School of Crete University Hospital, Heraklion, Greece aut Hunt Jennifer Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA aut Strojan Primož Department of Radiation Oncology, Institute of Oncology, Ljubljana, Slovenia aut Rinaldo Alessandra University of Udine School of Medicine, Piazzale S. Maria della Misericordia, 33100, Udine, Italy aut Takes Robert Department of Otolaryngology-Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands aut Ferlito Alfio University of Udine School of Medicine, Piazzale S. Maria della Misericordia, 33100, Udine, Italy aut de Bree Remco Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/5(2015-05-01), 1061-1077 0937-4477 272:5<1061 2015 272 405 https://doi.org/10.1007/s00405-014-3065-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3065-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- de Bree Eelco Department of Surgical Oncology, Medical School of Crete University Hospital, Heraklion, Greece aut NATIONALLICENCE 700 1- Karatzanis Alexander Department of Otolaryngology, Medical School of Crete University Hospital, Heraklion, Greece aut NATIONALLICENCE 700 1- Hunt Jennifer Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA aut NATIONALLICENCE 700 1- Strojan Primož Department of Radiation Oncology, Institute of Oncology, Ljubljana, Slovenia aut NATIONALLICENCE 700 1- Rinaldo Alessandra University of Udine School of Medicine, Piazzale S. Maria della Misericordia, 33100, Udine, Italy aut NATIONALLICENCE 700 1- Takes Robert Department of Otolaryngology-Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Ferlito Alfio University of Udine School of Medicine, Piazzale S. Maria della Misericordia, 33100, Udine, Italy aut NATIONALLICENCE 700 1- de Bree Remco Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/5(2015-05-01), 1061-1077 0937-4477 272:5<1061 2015 272 405