caa a22 4500 606186638 CHVBK 20210128100837.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00405-014-2906-9 doi (NATIONALLICENCE)springer-10.1007/s00405-014-2906-9 After myringotomy, can topical Mesna application be an alternative method to ventilation tube application? [Elektronische Daten] [Rifat Karli, Fatih Ilkaya, Arzu Karli, Emre Gunbey, Harun Kucuk, Hasan Guzel, Emre Ayhan] Sodium-2-mercaptoethanesulfonate (Mesna) is a mucolytic substance that is also used for chemically assisted tissue dissection in otological surgery. We investigated the effects of Mesna as a chemical agent on the closing time of perforation of the eardrum in an experimental animal model. We performed simple myringotomy with a knife on 44 tympanic membranes of 22 rats. Four rats were excluded from the study because of serosity in their ears. Rats were divided into two study groups and a control group. These groups were the Mesna-administered group (Group A) (8 rats, 15 tympanic membranes), the saline-administered group (Group B) (8 rats, 14 tympanic membranes) and the control (native) group (6 rats, 11 tympanic membranes) (Group C). We applied Mesna locally for 20min following myringotomy. Examination was made with an otoendoscope on days 1, 2, 3, 5, and 7, and patency rates were recorded. According to our results, we found that the closing time of the tympanic membrane was significantly longer in the Mesna group than in the saline administrated and native group. After myringotomy procedure, the application of a single dose of Mesna may contribute to the recovery duration of middle-ear pathologies by delaying the closing time of tympanic membrane perforation. However, Mesna cannot be an alternative method for the application of ventilation tubes. Springer-Verlag Berlin Heidelberg, 2014 Mesna nationallicence Myringotomy nationallicence Ventilation tube nationallicence Karli Rifat Department of Otorhinolaryngology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey aut Ilkaya Fatih Department of Medical Pharmacology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey aut Karli Arzu Department of Pediatric Infection, School of Medicine, Ondokuz Mayis University, Samsun, Turkey aut Gunbey Emre Department of Otorhinolaryngology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey aut Kucuk Harun Department of Otorhinolaryngology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey aut Guzel Hasan Department of Medical Pharmacology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey aut Ayhan Emre Department of Otorhinolaryngology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/5(2015-05-01), 1099-1102 0937-4477 272:5<1099 2015 272 405 https://doi.org/10.1007/s00405-014-2906-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-2906-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Karli Rifat Department of Otorhinolaryngology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey aut NATIONALLICENCE 700 1- Ilkaya Fatih Department of Medical Pharmacology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey aut NATIONALLICENCE 700 1- Karli Arzu Department of Pediatric Infection, School of Medicine, Ondokuz Mayis University, Samsun, Turkey aut NATIONALLICENCE 700 1- Gunbey Emre Department of Otorhinolaryngology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey aut NATIONALLICENCE 700 1- Kucuk Harun Department of Otorhinolaryngology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey aut NATIONALLICENCE 700 1- Guzel Hasan Department of Medical Pharmacology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey aut NATIONALLICENCE 700 1- Ayhan Emre Department of Otorhinolaryngology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/5(2015-05-01), 1099-1102 0937-4477 272:5<1099 2015 272 405