caa a22 4500 606186646 CHVBK 20210128100837.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00405-014-3183-3 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3183-3 Mucociliary transport and histopathological changes in rotation flaps of the nasal mucosa [Elektronische Daten] [Altay Ateşpare, Emre Üstündağ, Hakkı Dalçık, Öner Çelik] Normal mucociliary transport in the mucoperichondrium of the nasal septum is from a distal (anterior) to proximal (posterior) direction. This study was to determine the direction of mucociliary transport and histopathological changes in nasal mucosal rotation flaps when their transport directions were anatomically reversed. Thirty-two rabbits were divided into four groups. Surgical septal rotational flaps were prepared in the experimental groups. Group I was the control group. The distal aspect of the flap was sutured through a large septal window to the other side of the nasal septum, thus changing the direction of the flap. Evaluation was performed 1week, 1month and 9months later with each of these groups named as groups II, III, and IV, respectively. The rate and direction of the mucociliary transport was determined and histopathological investigations were performed from the flaps. The direction of mucociliary transport was observed to continue as distal to proximal direction in the rotated segments. The mucociliary transport rate was found to be decreased in group II, nearly normal in group III, and in normal limits in group IV after surgery. Intense inflammation and decreased number of cilia were present in group II. The inflammation was milder in group III and the epithelium was found to be nearly normal in group IV. The originally programmed direction of mucociliary transport in the nasal rotation flaps is maintained and is not altered or reprogrammed. Histopathological changes revert back to normal from an inflammatory state to reach pre-surgical status over time. Springer-Verlag Berlin Heidelberg, 2014 Nasal mucosa nationallicence Mucociliary transport nationallicence Mucociliary clearance nationallicence Mucosal regeneration nationallicence Ateşpare Altay Otolaryngology-Head and Neck Surgery Department, Maltepe University Medicine Faculty, Feyzullah Cad. No: 39, Maltepe, 34845, Istanbul, Turkey aut Üstündağ Emre Otolaryngology-Head and Neck Surgery Department, Acıbadem University Medicine Faculty, Istanbul, Turkey aut Dalçık Hakkı Department of Histology and Embryology, Kocaeli University Medicine Faculty, Kocaeli, Turkey aut Çelik Öner Otolaryngology-Head and Neck Surgery Department, Maltepe University Medicine Faculty, Feyzullah Cad. No: 39, Maltepe, 34845, Istanbul, Turkey aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/5(2015-05-01), 1143-1148 0937-4477 272:5<1143 2015 272 405 https://doi.org/10.1007/s00405-014-3183-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3183-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ateşpare Altay Otolaryngology-Head and Neck Surgery Department, Maltepe University Medicine Faculty, Feyzullah Cad. No: 39, Maltepe, 34845, Istanbul, Turkey aut NATIONALLICENCE 700 1- Üstündağ Emre Otolaryngology-Head and Neck Surgery Department, Acıbadem University Medicine Faculty, Istanbul, Turkey aut NATIONALLICENCE 700 1- Dalçık Hakkı Department of Histology and Embryology, Kocaeli University Medicine Faculty, Kocaeli, Turkey aut NATIONALLICENCE 700 1- Çelik Öner Otolaryngology-Head and Neck Surgery Department, Maltepe University Medicine Faculty, Feyzullah Cad. No: 39, Maltepe, 34845, Istanbul, Turkey aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/5(2015-05-01), 1143-1148 0937-4477 272:5<1143 2015 272 405