caa a22 4500 606186654 CHVBK 20210128100837.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00405-014-2922-9 doi (NATIONALLICENCE)springer-10.1007/s00405-014-2922-9 Vitamins A, C, and E and selenium in the treatment of idiopathic sudden sensorineural hearing loss [Elektronische Daten] [Hakan Kaya, Arzu Koç, İbrahim Sayın, Selçuk Güneş, Ahmet Altıntaş, Yakup Yeğin, Fatma Kayhan] This study evaluated the effectiveness of vitamins A, C, and E, with selenium, in the treatment of idiopathic sudden sensorineural hearing loss (ISSNHL). This was a prospective, controlled study performed at a tertiary teaching and research hospital. Over a 32-month period, patients were treated with either our standard ISSNHL treatment regimen plus vitamins A, C, and E and selenium (ACE+ group) or with only our standard ISSNHL treatment regimen (ACE− group). The demographics, additional symptoms, mean initial and final hearing levels, mean hearing gain, and recovery data were compared between the two groups. The ACE+ group, consisting of 70 (55.5%) patients, received vitamin A (natural beta-carotene, 26,000IU), vitamin C (ascorbic acid, 200mg), vitamin E (d-alpha-tocopherol, 200IU), and selenium (50μg) twice daily for 30days in addition to our ISSNHL treatment regimen: methylprednisolone at an initial dose of 1mg/kg body weight per day, tapered over 14days; Rheomacrodex® [(10g of dextran and 0.9g of NaCl)/100ml] 500ml daily for 5days; Vastarel® 20-mg tablet (20mg of trimetazidine dihydrochloride) three times daily for 30days; and ten 60-min hyperbaric oxygen (HBO) sessions (2.5 absolute atmospheres of 100% O2), once daily, starting the day of hospitalization. The ACE− group comprised 56 (44.4%) patients, who received only our ISSNHL treatment regimen. The mean hearing gains were 36.2±20.3dB in the ACE+ group and 27.1±20.6dB in the ACE− group. The mean hearing gain rates were significantly higher in the ACE+ group than in the ACE− group (p=0.014). Treatment with vitamins A, C, and E and selenium was effective in ISSNHL patients undergoing treatment with methylprednisolone, dextran, trimetazidine dihydrochloride, and HBO, and might be more effective when the initial hearing level is below 46dB. Springer-Verlag Berlin Heidelberg, 2014 Antioxidant nationallicence Idiopathic sudden sensorineural hearing loss nationallicence Kaya Hakan E.N.T Clinic, Bakırköy Dr.Sadi Konuk Teaching and Research Hospital, Tevfik Sağlam Cad. No: 11, Zuhuratbaba, 34417, Istanbul, Turkey aut Koç Arzu E.N.T Clinic, Bakırköy Dr.Sadi Konuk Teaching and Research Hospital, Tevfik Sağlam Cad. No: 11, Zuhuratbaba, 34417, Istanbul, Turkey aut Sayın İbrahim E.N.T Clinic, Bakırköy Dr.Sadi Konuk Teaching and Research Hospital, Tevfik Sağlam Cad. No: 11, Zuhuratbaba, 34417, Istanbul, Turkey aut Güneş Selçuk E.N.T Clinic, Bakırköy Dr.Sadi Konuk Teaching and Research Hospital, Tevfik Sağlam Cad. No: 11, Zuhuratbaba, 34417, Istanbul, Turkey aut Altıntaş Ahmet E.N.T Clinic, Bakırköy Dr.Sadi Konuk Teaching and Research Hospital, Tevfik Sağlam Cad. No: 11, Zuhuratbaba, 34417, Istanbul, Turkey aut Yeğin Yakup E.N.T Clinic, Bakırköy Dr.Sadi Konuk Teaching and Research Hospital, Tevfik Sağlam Cad. No: 11, Zuhuratbaba, 34417, Istanbul, Turkey aut Kayhan Fatma E.N.T Clinic, Bakırköy Dr.Sadi Konuk Teaching and Research Hospital, Tevfik Sağlam Cad. No: 11, Zuhuratbaba, 34417, Istanbul, Turkey aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/5(2015-05-01), 1119-1125 0937-4477 272:5<1119 2015 272 405 https://doi.org/10.1007/s00405-014-2922-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-2922-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kaya Hakan E.N.T Clinic, Bakırköy Dr.Sadi Konuk Teaching and Research Hospital, Tevfik Sağlam Cad. No: 11, Zuhuratbaba, 34417, Istanbul, Turkey aut NATIONALLICENCE 700 1- Koç Arzu E.N.T Clinic, Bakırköy Dr.Sadi Konuk Teaching and Research Hospital, Tevfik Sağlam Cad. No: 11, Zuhuratbaba, 34417, Istanbul, Turkey aut NATIONALLICENCE 700 1- Sayın İbrahim E.N.T Clinic, Bakırköy Dr.Sadi Konuk Teaching and Research Hospital, Tevfik Sağlam Cad. No: 11, Zuhuratbaba, 34417, Istanbul, Turkey aut NATIONALLICENCE 700 1- Güneş Selçuk E.N.T Clinic, Bakırköy Dr.Sadi Konuk Teaching and Research Hospital, Tevfik Sağlam Cad. No: 11, Zuhuratbaba, 34417, Istanbul, Turkey aut NATIONALLICENCE 700 1- Altıntaş Ahmet E.N.T Clinic, Bakırköy Dr.Sadi Konuk Teaching and Research Hospital, Tevfik Sağlam Cad. No: 11, Zuhuratbaba, 34417, Istanbul, Turkey aut NATIONALLICENCE 700 1- Yeğin Yakup E.N.T Clinic, Bakırköy Dr.Sadi Konuk Teaching and Research Hospital, Tevfik Sağlam Cad. No: 11, Zuhuratbaba, 34417, Istanbul, Turkey aut NATIONALLICENCE 700 1- Kayhan Fatma E.N.T Clinic, Bakırköy Dr.Sadi Konuk Teaching and Research Hospital, Tevfik Sağlam Cad. No: 11, Zuhuratbaba, 34417, Istanbul, Turkey aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/5(2015-05-01), 1119-1125 0937-4477 272:5<1119 2015 272 405