caa a22 4500 606186689 CHVBK 20210128100837.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00405-014-2904-y doi (NATIONALLICENCE)springer-10.1007/s00405-014-2904-y Effects of polylactic acid film on middle ear mucosa and cochlear function in Guinea pigs [Elektronische Daten] [Nuray Ensari, Hakan Tutar, Ozgur Ekinci, Mehmet Ugur, Yıldırım Bayazıt, Cagil Gokdogan, Nebil Goksu] Our aim was to assess the effects of polylactic acid (PLA) on middle ear mucosa and cochlea, to be used as a film barrier for postoperative adhesion prevention in the middle ear. Twenty-one albino Guinea pigs were included in the study. A window was opened on both tympanic bulla and on one side PLA material was placed in the middle ear and on the other side only fenestration was performed and used as a control. All Guinea pigs underwent evaluation of tympanic membranes microscopically; functional hearing was analyzed by auditory brainstem responses preoperatively, in the first and the sixth month. All Guinea pigs were killed on the sixth month for histopathologic evaluation of their temporal bones. There was no statistical difference between both groups regarding hearing thresholds, interpeak wave latencies preoperatively and on first and the sixth months postoperatively. Histopathological evaluation revealed no specific changes. There was a mild local inflammation both in the PLA implanted and control ears. PLA film barrier most likely has no toxic effects on Guinea pig middle ear and does not show any ototoxic side effects. Springer-Verlag Berlin Heidelberg, 2014 Polylactic acid nationallicence Ototoxicity nationallicence Middle ear effects nationallicence Inner ear effects nationallicence Adhesive otitis media nationallicence Biomaterial nationallicence Ensari Nuray Department of Otolaryngology, Antalya Atatürk Education and Research Hospital, Antalya, Turkey aut Tutar Hakan Department of Otolaryngology, Faculty of Medicine, Gazi University, Ankara, Turkey aut Ekinci Ozgur Department of Pathology, Faculty of Medicine, Gazi University, Ankara, Turkey aut Ugur Mehmet Department of Otolaryngology, Faculty of Medicine, Gazi University, Ankara, Turkey aut Bayazıt Yıldırım Department of Otolaryngology, Faculty of Medicine, Gazi University, Ankara, Turkey aut Gokdogan Cagil Audiology Unit, Faculty of Medicine, Gazi University, Ankara, Turkey aut Goksu Nebil Department of Otolaryngology, Faculty of Medicine, Gazi University, Ankara, Turkey aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/5(2015-05-01), 1091-1097 0937-4477 272:5<1091 2015 272 405 https://doi.org/10.1007/s00405-014-2904-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-2904-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ensari Nuray Department of Otolaryngology, Antalya Atatürk Education and Research Hospital, Antalya, Turkey aut NATIONALLICENCE 700 1- Tutar Hakan Department of Otolaryngology, Faculty of Medicine, Gazi University, Ankara, Turkey aut NATIONALLICENCE 700 1- Ekinci Ozgur Department of Pathology, Faculty of Medicine, Gazi University, Ankara, Turkey aut NATIONALLICENCE 700 1- Ugur Mehmet Department of Otolaryngology, Faculty of Medicine, Gazi University, Ankara, Turkey aut NATIONALLICENCE 700 1- Bayazıt Yıldırım Department of Otolaryngology, Faculty of Medicine, Gazi University, Ankara, Turkey aut NATIONALLICENCE 700 1- Gokdogan Cagil Audiology Unit, Faculty of Medicine, Gazi University, Ankara, Turkey aut NATIONALLICENCE 700 1- Goksu Nebil Department of Otolaryngology, Faculty of Medicine, Gazi University, Ankara, Turkey aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/5(2015-05-01), 1091-1097 0937-4477 272:5<1091 2015 272 405