caa a22 4500 606186735 CHVBK 20210128100837.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00405-014-2974-x doi (NATIONALLICENCE)springer-10.1007/s00405-014-2974-x Management of Merkel cell carcinoma of unknown primary origin: the Vienna Medical School experience [Elektronische Daten] [Georg Haymerle, Alexandra Fochtmann, Rainer Kunstfeld, Johannes Pammer, Boban Erovic] Merkel cell carcinoma is a rare, but highly aggressive skin tumor. We describe our single-institution experience with the diagnosis and treatment of Merkel cell carcinoma of unknown primary (MCCUP). We conducted a retrospective medical chart review of patients treated with MCCUP at the Vienna General Hospital between 2002 and 2011. Clinicopathologic variables and outcomes were analyzed. Of the entire cohort of 57 patients, 8 patients (14%) were diagnosed with MCCUP. Three patients presented with parotid gland involvement, four patients with positive inguinal lymph nodes and one with axillar lymph nodes. CK20 staining was positive in all tumor specimens, whereas MCPyV protein was positive in four out of six patients. The primary surgical modality in five cases was wide local excision. In one patient excisional biopsy was followed by re-resection. In one case only excisional biopsy was performed due to metastatic disease at first diagnosis. Two patients underwent concomitant parotidectomy and neck dissection, and four patients received adjuvant radiation therapy. Median recurrence-free survival was 20months. Four patients died, three of disease and one of other cause. Recurrent disease was observed in two patients and treated with radiotherapy and chemotherapy. The 1- and 3-year overall survival rates were 87.5 and 37.5%, respectively. The 1- and 3-year disease-specific survival rates were 87.5 and 62.5%, respectively. Our study shows a poor outcome in patients with MCCUP, particularly in patients with node involvement of the trunk. We therefore suggest an aggressive and multimodal treatment approach for patients with MCCUP. Springer-Verlag Berlin Heidelberg, 2014 Merkel cell carcinoma of unknown primary nationallicence Retrospective nationallicence Haymerle Georg Department of Otolaryngology Head and Neck Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria aut Fochtmann Alexandra Department of Otolaryngology Head and Neck Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria aut Kunstfeld Rainer Department of Dermatology, Medical University of Vienna, Vienna, Austria aut Pammer Johannes Department of Clinical Pathology, Medical University of Vienna, Vienna, Austria aut Erovic Boban Department of Otolaryngology Head and Neck Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/2(2015-02-01), 425-429 0937-4477 272:2<425 2015 272 405 https://doi.org/10.1007/s00405-014-2974-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-2974-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Haymerle Georg Department of Otolaryngology Head and Neck Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Fochtmann Alexandra Department of Otolaryngology Head and Neck Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Kunstfeld Rainer Department of Dermatology, Medical University of Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Pammer Johannes Department of Clinical Pathology, Medical University of Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Erovic Boban Department of Otolaryngology Head and Neck Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/2(2015-02-01), 425-429 0937-4477 272:2<425 2015 272 405