caa a22 4500 60618676X CHVBK 20210128100837.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00405-014-3368-9 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3368-9 CO2 laser cordectomy for glottic squamous cell carcinoma involving the anterior commissure: voice and oncologic outcomes [Elektronische Daten] [Abie Mendelsohn, Devora Kiagiadaki, Georges Lawson, Marc Remacle] Transoral CO2 laser cordectomy for squamous cell carcinoma (SCC) of the glottis has resulted in excellent voice and oncologic outcomes as compared with non-surgical therapy. However, published experience with primary CO2 laser cordectomy specifically for glottic SCC involving the anterior commissure (AC) is limited. A review of single academic institution experience with CO2 laser cordectomy for glottic SCC involving the AC. Patients undergoing European Laryngological Society (ELS) classification cordectomy type Va or type VI between 2005 and 2013 were included. Post-surgical voice analysis was performed by speech language pathologists (SLP) from the reporting institution. Thirty patients were identified for inclusion. Mean post-surgical follow-up time was 47.6months (range 11-59). Initial local recurrence was identified in 5/30 (16.7%) patients. 2/5 recurrences were successfully salvaged by repeat CO2 laser resections, 2/5 ultimately required salvage total laryngectomy, and 1/5 patient developed a second primary preventing further curative treatment. Overall laryngeal preservation rate was 28/30 (93.3%). Overall survival of the study cohort was 96.7%. Mean postoperative voice handicap index-120 score was 36.9 (SD=21.4). Perceptual analysis performed on the GRBAS scale resulted in mean scores: G=2.1 (SD=0.9), R=1.3 (SD=1.1), B=1.6 (SD=1.2). Though cancers involving the AC represent an aggressive subgroup of glottic SCC, CO2 laser cordectomy results in encouraging oncologic and voice outcomes without the need for further therapy in the majority of cases. Clinical trials are encouraged to further define optimal treatment recommendations for glottic SCC involving the AC. Springer-Verlag Berlin Heidelberg, 2014 Larynx nationallicence Laryngeal cancer nationallicence Vocal cord nationallicence Vocal fold nationallicence Carcinoma nationallicence Cancer nationallicence Radiation nationallicence Mendelsohn Abie Department of Head and Neck Surgery, Head and Neck Robotic Surgery Program, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA aut Kiagiadaki Devora Head and Neck Surgery Department, Catholic University of Louvain at Mont-Godinne, Yvoir, Belgium aut Lawson Georges Head and Neck Surgery Department, Catholic University of Louvain at Mont-Godinne, Yvoir, Belgium aut Remacle Marc Head and Neck Surgery Department, Catholic University of Louvain at Mont-Godinne, Yvoir, Belgium aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/2(2015-02-01), 413-418 0937-4477 272:2<413 2015 272 405 https://doi.org/10.1007/s00405-014-3368-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3368-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mendelsohn Abie Department of Head and Neck Surgery, Head and Neck Robotic Surgery Program, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Kiagiadaki Devora Head and Neck Surgery Department, Catholic University of Louvain at Mont-Godinne, Yvoir, Belgium aut NATIONALLICENCE 700 1- Lawson Georges Head and Neck Surgery Department, Catholic University of Louvain at Mont-Godinne, Yvoir, Belgium aut NATIONALLICENCE 700 1- Remacle Marc Head and Neck Surgery Department, Catholic University of Louvain at Mont-Godinne, Yvoir, Belgium aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/2(2015-02-01), 413-418 0937-4477 272:2<413 2015 272 405