caa a22 4500 606186905 CHVBK 20210128100838.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00405-013-2851-z doi (NATIONALLICENCE)springer-10.1007/s00405-013-2851-z Medium-term results of combined treatment with transcranial magnetic stimulation and antidepressant drug for chronic tinnitus [Elektronische Daten] [Suat Bilici, Ozgur Yigit, Umit Taskin, Ayse Gor, Enver Yilmaz] We compared the effects of repetitive transcranial magnetic stimulation (rTMS) and paroxetine [a selective serotonin reuptake inhibitor (SSRI)] on tinnitus in terms of effectiveness and medium-term results. This is a randomised, double-blind, placebo-controlled study. Seventy-five patients with moderate tinnitus were divided into five equal groups. Each group was treated for 1month as follows: group 1 received rTMS alone at 1Hz frequency; group 2 received rTMS alone at 10Hz frequency; group 3 received rTMS at 1Hz frequency combined with paroxetine; group 4 received paroxetine alone; and group 5 received a placebo (sham rTMS). Participants were tested using the Tinnitus Handicap Inventory (THI), Tinnitus Severity Index (TSI), the Beck Anxiety Scoring (BAS), and Psychiatric Sign Screening (PSS) tests. THI, TSI, BAS, and PSS were measured prior to treatment, and at the first and sixth month post-treatment. The THI and TSI scores improved after treatment in all groups, except the placebo group. The THI scores in groups 1 and 2 showed a statistically significant improvement after the first and sixth month compared to pretreatment scores, whereas a significant improvement in THI scores occurred only after the sixth month in groups 3 and 4. The TSI scores in group 3 showed a significant improvement at the first and sixth month marks after treatment. The rTMS and SSRI play potential roles in the reduction of tinnitus severity, but without cumulative or synergistic effects when a combination of treatment regimens is applied. These positive effects might be due to the relationship between the auditory cortex areas related to emotions and tinnitus. Springer-Verlag Berlin Heidelberg, 2013 Repetitive transcranial magnetic stimulation (rTMS) nationallicence Tinnitus nationallicence Selective serotonin reuptake inhibitor nationallicence Clinical trial nationallicence Bilici Suat Department of Otorhinolaryngology, Istanbul Research and Training Hospital, Istanbul, Turkey aut Yigit Ozgur Department of Otorhinolaryngology, Istanbul Research and Training Hospital, Istanbul, Turkey aut Taskin Umit Department of Otorhinolaryngology, Bagcilar Research and Training Hospital, Istanbul, Turkey aut Gor Ayse Division of Otorhinolaryngology, Catalca State Hospital, Istanbul, Turkey aut Yilmaz Enver Division of Psychiatry, Istanbul Research and Training Hospital, Istanbul, Turkey aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/2(2015-02-01), 337-343 0937-4477 272:2<337 2015 272 405 https://doi.org/10.1007/s00405-013-2851-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-013-2851-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bilici Suat Department of Otorhinolaryngology, Istanbul Research and Training Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Yigit Ozgur Department of Otorhinolaryngology, Istanbul Research and Training Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Taskin Umit Department of Otorhinolaryngology, Bagcilar Research and Training Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Gor Ayse Division of Otorhinolaryngology, Catalca State Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Yilmaz Enver Division of Psychiatry, Istanbul Research and Training Hospital, Istanbul, Turkey aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/2(2015-02-01), 337-343 0937-4477 272:2<337 2015 272 405