caa a22 4500 606186913 CHVBK 20210128100838.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00405-014-3323-9 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3323-9 Epidermal growth factor receptor (EGFR) expression in patients with laryngeal squamous cell carcinoma [Elektronische Daten] [Mirko Kontić, Jovica Milovanović, Zaviša Čolović, Nikola Poljak, Željko Šundov, Ante Sučić, Valdi Pešutić-Pisac] To assess the epidermal growth factor receptor (EGFR) correlation with histopathologic and clinical characteristics of laryngeal squamous cell carcinoma (SCC) and the impact of EGFR overexpression on patient survival. This retrospective study included 185 SCC patients treated at Clinical Department of ENT, Head and Neck Surgery, Split University Hospital Center between January 1, 2000 and December 31, 2009. A statistically significant correlation (p<0.001) was recorded between the level of EGFR expression and SCC histopathologic grade, stage, metastasizing potential, relapsing potential, and patient survival. Kaplan-Meier survival curve yielded a statistically significant difference (χ 2=75.05; p<0.001) among the four patient groups with different levels of EGFR expression. The higher the level of EGFR expression, the poorer is the patient prognosis and survival. In our study, expression of EGFR as a biomarker showed a potential predictive value in laryngeal SCC. Springer-Verlag Berlin Heidelberg, 2014 Epidermal growth factor receptor nationallicence EGFR nationallicence Squamous cell carcinoma nationallicence Larynx nationallicence Survival nationallicence Kontić Mirko ENT Department, University of Split School of Medicine, University Hospital Centre Split, Split, Croatia aut Milovanović Jovica University of Belgrade School of Medicine, Belgrade, Serbia aut Čolović Zaviša ENT Department, University of Split School of Medicine, University Hospital Centre Split, Split, Croatia aut Poljak Nikola ENT Department, University of Split School of Medicine, University Hospital Centre Split, Split, Croatia aut Šundov Željko Department of Internal Medicine, University of Split School of Medicine, University Hospital Centre Split, Split, Croatia aut Sučić Ante ENT Department, University Hospital Centre Split, Split, Croatia aut Pešutić-Pisac Valdi Department of Pathology, University of Split School of Medicine, University Hospital Centre Split, Split, Croatia aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/2(2015-02-01), 401-405 0937-4477 272:2<401 2015 272 405 https://doi.org/10.1007/s00405-014-3323-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3323-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kontić Mirko ENT Department, University of Split School of Medicine, University Hospital Centre Split, Split, Croatia aut NATIONALLICENCE 700 1- Milovanović Jovica University of Belgrade School of Medicine, Belgrade, Serbia aut NATIONALLICENCE 700 1- Čolović Zaviša ENT Department, University of Split School of Medicine, University Hospital Centre Split, Split, Croatia aut NATIONALLICENCE 700 1- Poljak Nikola ENT Department, University of Split School of Medicine, University Hospital Centre Split, Split, Croatia aut NATIONALLICENCE 700 1- Šundov Željko Department of Internal Medicine, University of Split School of Medicine, University Hospital Centre Split, Split, Croatia aut NATIONALLICENCE 700 1- Sučić Ante ENT Department, University Hospital Centre Split, Split, Croatia aut NATIONALLICENCE 700 1- Pešutić-Pisac Valdi Department of Pathology, University of Split School of Medicine, University Hospital Centre Split, Split, Croatia aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/2(2015-02-01), 401-405 0937-4477 272:2<401 2015 272 405