caa a22 4500 606186972 CHVBK 20210128100838.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00405-014-2980-z doi (NATIONALLICENCE)springer-10.1007/s00405-014-2980-z Clinicopathological characteristics of carcinoma from unknown primary in cervical lymph nodes [Elektronische Daten] [Daniel Weiss, Mario Koopmann, Markus Stenner, Eleftherios Savvas, Claudia Rudack] Carcinoma in cervical lymph nodes of unknown origin represents a rare clinical entity where optimal diagnostic and therapeutic management is still a widely debated issue. Molecular classification of these metastases is thus of utmost importance. We analyzed the expression of eight basic molecular markers in 26 metastases from unknown primaries, 31 metastases from overt primaries and their associated primaries. Medical records of the respective patients were reviewed for main clinicopathological parameters. The expression rates showed no significant differences between the two tumor entities, neither in absolute terms nor in comparison among the parameters. Surprisingly, patients with metastases from unknown primary demonstrated improved progression-free survival (p=0.046) despite advanced age (p=0.029), advanced nodal stage (p=0.006) and higher incidence of extracapsular spread (p=0.045) compared to patients with metastases from overt primaries. Presence of extracapsular spread was associated with increased expression of epidermal growth factor receptor in metastases from overt primaries (p=0.035) and reduced expression of matrix metalloproteinase-2 in metastases from unknown primary (p=0.031). We thus conclude that cervical metastases from unknown and overt primaries show similarities in their molecular profile, but fundamental differences in clinical parameter. Springer-Verlag Berlin Heidelberg, 2014 Carcinoma of unknown primary in cervical lymph nodes nationallicence Head and neck squamous cell carcinoma nationallicence Molecular profile nationallicence Survival nationallicence Weiss Daniel Department of Otorhinolaryngology, Head and Neck Surgery, University of Münster, Kardinal-von-Galen-Ring 10, 48149, Münster, Germany aut Koopmann Mario Department of Otorhinolaryngology, Head and Neck Surgery, University of Münster, Kardinal-von-Galen-Ring 10, 48149, Münster, Germany aut Stenner Markus Department of Otorhinolaryngology, Head and Neck Surgery, University of Münster, Kardinal-von-Galen-Ring 10, 48149, Münster, Germany aut Savvas Eleftherios Department of Otorhinolaryngology, Head and Neck Surgery, University of Münster, Kardinal-von-Galen-Ring 10, 48149, Münster, Germany aut Rudack Claudia Department of Otorhinolaryngology, Head and Neck Surgery, University of Münster, Kardinal-von-Galen-Ring 10, 48149, Münster, Germany aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/2(2015-02-01), 431-437 0937-4477 272:2<431 2015 272 405 https://doi.org/10.1007/s00405-014-2980-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-2980-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Weiss Daniel Department of Otorhinolaryngology, Head and Neck Surgery, University of Münster, Kardinal-von-Galen-Ring 10, 48149, Münster, Germany aut NATIONALLICENCE 700 1- Koopmann Mario Department of Otorhinolaryngology, Head and Neck Surgery, University of Münster, Kardinal-von-Galen-Ring 10, 48149, Münster, Germany aut NATIONALLICENCE 700 1- Stenner Markus Department of Otorhinolaryngology, Head and Neck Surgery, University of Münster, Kardinal-von-Galen-Ring 10, 48149, Münster, Germany aut NATIONALLICENCE 700 1- Savvas Eleftherios Department of Otorhinolaryngology, Head and Neck Surgery, University of Münster, Kardinal-von-Galen-Ring 10, 48149, Münster, Germany aut NATIONALLICENCE 700 1- Rudack Claudia Department of Otorhinolaryngology, Head and Neck Surgery, University of Münster, Kardinal-von-Galen-Ring 10, 48149, Münster, Germany aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/2(2015-02-01), 431-437 0937-4477 272:2<431 2015 272 405