caa a22 4500 606186999 CHVBK 20210128100838.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00405-014-3012-8 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3012-8 Topical anesthetic preparations for rigid and flexible endoscopy: a meta-analysis [Elektronische Daten] [Se Hwang, Chan-Soon Park, Byung Kim, Jin Cho, Jun Kang] Transnasal endoscopy can cause pain or discomfort for the patient. Topical anesthetic has been used in an attempt to reduce this. However, there is no consensus on whether topical anesthetic is effective in optimizing patient experience during the procedure. The goal of this study was to perform a systematic review with meta-analysis of the efficacy of topical anesthetic on pain and comfort outcomes during endoscopy. Two authors independently searched the databases from inception to September 2013. Studies comparing topical anesthetic with placebo where the outcomes of interest were pain, comfort, or side effect outcomes were included. Sufficient data for meta-analysis were retrieved for ten trials with a total of 837 patients. The evidence suggests that local anesthetic alone or in combination with a vasoconstrictor is beneficial to patients' pain [standardized mean difference (SMD)=−0.21; p=0.045] and comfort (SMD=−0.51; p<0.001) outcomes when performing transnasal endoscopy. However, the topical anesthetic caused unpleasant sensation with respect to an unpleasant taste (SMD=0.77; p<0.001). In addition, there was no significant difference between a topical anesthetic spray and cotton type in pain and discomfort values. Applying topical anesthetic during transnasal endoscopy could reduce pain and discomfort. The spray and cotton type methods of topical anesthetic preparation showed no significant difference in terms of pain and discomfort during the procedure. However, further trials with good research methodology should be conducted to confirm our results. Springer-Verlag Berlin Heidelberg, 2014 Endoscopy nationallicence Nose nationallicence Anesthesia nationallicence Topical nationallicence Patient-reported outcome measures nationallicence Systematic review nationallicence Meta-analysis nationallicence Hwang Se Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Bucheon St. Mary'ss Hospital, The Catholic University of Korea, 327 Sosa-ro, Wonmi-gu, 420-717, Bucheon-city, Gyeonggi-do, Republic of Korea aut Park Chan-Soon Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Bucheon St. Mary'ss Hospital, The Catholic University of Korea, 327 Sosa-ro, Wonmi-gu, 420-717, Bucheon-city, Gyeonggi-do, Republic of Korea aut Kim Byung Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Bucheon St. Mary'ss Hospital, The Catholic University of Korea, 327 Sosa-ro, Wonmi-gu, 420-717, Bucheon-city, Gyeonggi-do, Republic of Korea aut Cho Jin Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Bucheon St. Mary'ss Hospital, The Catholic University of Korea, 327 Sosa-ro, Wonmi-gu, 420-717, Bucheon-city, Gyeonggi-do, Republic of Korea aut Kang Jun Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Bucheon St. Mary'ss Hospital, The Catholic University of Korea, 327 Sosa-ro, Wonmi-gu, 420-717, Bucheon-city, Gyeonggi-do, Republic of Korea aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/2(2015-02-01), 263-270 0937-4477 272:2<263 2015 272 405 https://doi.org/10.1007/s00405-014-3012-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3012-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hwang Se Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Bucheon St. Mary'ss Hospital, The Catholic University of Korea, 327 Sosa-ro, Wonmi-gu, 420-717, Bucheon-city, Gyeonggi-do, Republic of Korea aut NATIONALLICENCE 700 1- Park Chan-Soon Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Bucheon St. Mary'ss Hospital, The Catholic University of Korea, 327 Sosa-ro, Wonmi-gu, 420-717, Bucheon-city, Gyeonggi-do, Republic of Korea aut NATIONALLICENCE 700 1- Kim Byung Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Bucheon St. Mary'ss Hospital, The Catholic University of Korea, 327 Sosa-ro, Wonmi-gu, 420-717, Bucheon-city, Gyeonggi-do, Republic of Korea aut NATIONALLICENCE 700 1- Cho Jin Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Bucheon St. Mary'ss Hospital, The Catholic University of Korea, 327 Sosa-ro, Wonmi-gu, 420-717, Bucheon-city, Gyeonggi-do, Republic of Korea aut NATIONALLICENCE 700 1- Kang Jun Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Bucheon St. Mary'ss Hospital, The Catholic University of Korea, 327 Sosa-ro, Wonmi-gu, 420-717, Bucheon-city, Gyeonggi-do, Republic of Korea aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/2(2015-02-01), 263-270 0937-4477 272:2<263 2015 272 405