caa a22 4500 606187006 CHVBK 20210128100838.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00405-014-3299-5 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3299-5 MicroRNA-10a-5p and microRNA-34c-5p in laryngeal epithelial premalignant lesions: differential expression and clinicopathological correlation [Elektronische Daten] [Yanping Hu, Honggang Liu] This study was to analyze the dys-regulation of microRNA-10a-5p and microRNA-34c-5p and their correlations with clinicopathological characteristics of laryngeal epithelial premalignant lesions (LEPL). Quantitative real-time polymerase chain reaction was performed to detect the expression of microRNA-10a-5p and microRNA-34c-5p in 94 cases of LEPL and 47 controls. Retrospective follow-up data of all patients were collected and the correlation between the dys-regulation of microRNA-10a-5p/microRNA-34c-5p and clinicopathological characteristics was examined by linear regression analysis. Expression of microRNA-10a-5p was down-regulated in LEPL, showing statistical difference between low-risk lesion group and high-risk lesion group, while microRNA-34c-5p expression was up-regulated gradually in LEPL groups and dropped suddenly in squamous cell carcinoma group. In addition, the differential expression of microRNA-10a-5p is profiled with either LEPL grade or gender, showing a linear correlation; and microRNA-34c-5p expression is correlated with alcohol consumption in LEPL patients (P<0.05). The dys-regulation of microRNA-10a-5p and microRNA-34c-5p in LEPL and their correlations with clinicopathological characteristics might provide important theoretical and experimental basis for LEPL classfication and the two microRNAs can serve as more valuable markers in diagnosis and clinical management of LEPL. Springer-Verlag Berlin Heidelberg, 2014 Larynx nationallicence Premalignant lesions nationallicence MicroRNA-10a-5p nationallicence MicroRNA-34c-5p nationallicence Clinicopathological correlation nationallicence Hu Yanping Department of Pathology, Beijing TongRen Hospital, Capital Medical University, Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, 100730, Beijing, China aut Liu Honggang Department of Pathology, Beijing TongRen Hospital, Capital Medical University, Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, 100730, Beijing, China aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/2(2015-02-01), 391-399 0937-4477 272:2<391 2015 272 405 https://doi.org/10.1007/s00405-014-3299-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3299-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hu Yanping Department of Pathology, Beijing TongRen Hospital, Capital Medical University, Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, 100730, Beijing, China aut NATIONALLICENCE 700 1- Liu Honggang Department of Pathology, Beijing TongRen Hospital, Capital Medical University, Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, 100730, Beijing, China aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/2(2015-02-01), 391-399 0937-4477 272:2<391 2015 272 405