caa a22 4500 606187014 CHVBK 20210128100838.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00405-014-3096-1 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3096-1 The effect of nasal structure on olfactory function in patients with OSA [Elektronische Daten] [Dan Fu, Jayant Pinto, Li Wang, Guowei Chen, Xiaojun Zhan, Yongxiang Wei] The aim of this study was to investigate the relationship between nasal structure and olfactory function in patients with obstructive sleep apnea (OSA). Olfaction and nasal structure of 76 adults with OSA diagnosed by polysomnography were measured using acoustic rhinometry and the Sniffin, Sticks (SS) smell test at Anzhen Hospital, a major academic center in Beijing, China. We tested the hypothesis that nasal structure in these patients would correlate with objectively measured olfactory performance. Minimum cross-sectional area (MCA) of the nose was significantly correlated with SS composite score (r=0.434, p<0.001), a result that was driven by two of the test's three components: olfactory threshold (OT) (r=0.385, p=0.001) and olfactory discrimination (OD) (r=0.370, p=0.001) but not olfactory identification (OI) (p>0.05). Additionally, nasal volume (NV) was associated with composite SS score (r=0.350, p=0.002), a finding driven by OT (r=0.283, p=0.014). These data suggest that nasal structure affects parameters of olfactory function, likely via alterations in nasal airflow. Thus, anatomic abnormalities and diseases involving airflow (such as OSA) may cause, in part, olfactory dysfunction that is amenable to treatment. We speculate that surgery that alters nasal volume and MCA may improve olfactory performance. Springer-Verlag Berlin Heidelberg, 2014 Olfactory function nationallicence Nasal structure nationallicence Acoustic rhinometry nationallicence Obstructive sleep apnea nationallicence Fu Dan Department of Otolaryngology-Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, 2 Anzhen Road, Chaoyang District, Beijing, People's Republic of China aut Pinto Jayant Section of Otolaryngology-Head and Neck Surgery, Department of Surgery, The University of Chicago, Chicago, IL, USA aut Wang Li Department of Respiration, Beijing Anzhen Hospital, Capital Medical University, Beijing, People's Republic of China aut Chen Guowei Department of Otolaryngology, Children's Hospital, Shenzhen, People's Republic of China aut Zhan Xiaojun Department of Otolaryngology-Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, 2 Anzhen Road, Chaoyang District, Beijing, People's Republic of China aut Wei Yongxiang Department of Otolaryngology-Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, 2 Anzhen Road, Chaoyang District, Beijing, People's Republic of China aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/2(2015-02-01), 357-362 0937-4477 272:2<357 2015 272 405 https://doi.org/10.1007/s00405-014-3096-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3096-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fu Dan Department of Otolaryngology-Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, 2 Anzhen Road, Chaoyang District, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Pinto Jayant Section of Otolaryngology-Head and Neck Surgery, Department of Surgery, The University of Chicago, Chicago, IL, USA aut NATIONALLICENCE 700 1- Wang Li Department of Respiration, Beijing Anzhen Hospital, Capital Medical University, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Chen Guowei Department of Otolaryngology, Children's Hospital, Shenzhen, People's Republic of China aut NATIONALLICENCE 700 1- Zhan Xiaojun Department of Otolaryngology-Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, 2 Anzhen Road, Chaoyang District, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Wei Yongxiang Department of Otolaryngology-Head and Neck Surgery, Beijing Anzhen Hospital, Capital Medical University, 2 Anzhen Road, Chaoyang District, Beijing, People's Republic of China aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/2(2015-02-01), 357-362 0937-4477 272:2<357 2015 272 405