caa a22 4500 606187030 CHVBK 20210128100839.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00405-014-3023-5 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3023-5 Efficacy of sucralfate for the treatment of post-tonsillectomy symptoms [Elektronische Daten] [Nora Siupsinskiene, Jurgita Žekonienė, Evaldas Padervinskis, Gediminas Žekonis, Saulius Vaitkus] Pain after tonsillectomy remains the main issue of postoperative morbidity and the search for an effective post-tonsillectomy analgesic is of increasing relevance. The aim of this study was to evaluate the effectiveness of topical sucralfate during an early post-tonsillectomy period. Fifty patients of both genders from 6 to 58years submitted to tonsillectomy or adenotonsillectomy were randomly included into either a sucralfate treatment group (N=25) or into a control group (N=25). Patients of the sucralfate group received topical sucralfate four times a day for 7days. No topical treatment was applied to patients of the control group. A systemic analgesic was standardized. Post-tonsillectomy symptoms, including throat pain, odynophagia and otalgia, were evaluated during the period of seven postoperative days. Secondary outcomes were analgesic use, well being in general, return to regular daily activities, secondary hemorrhage and side effects of sucralfate. This study revealed that during the period of the second to seventh postoperative days average throat pain scores of the sucralfate using patients were significantly lower than those of the control group patients (p<0.05); the same could be applied to odynophagia scores during the period of all seven postoperative days (p<0.01) and otalgia scores from the 4th postoperative day (p<0.05). The sucralfate group patients also had a significantly smaller need for analgesics, better scores of well being in general and early return to regular daily activities with no side effects of the treatment. Topical sucralfate could be recommended for the everyday clinical practice as a safe, adjuvant medicine of treatment during the period of the first post-tonsillectomy week. Springer-Verlag Berlin Heidelberg, 2014 Tonsillectomy nationallicence Postoperative pain nationallicence Sucralfate nationallicence Morbidity nationallicence Siupsinskiene Nora Department of Otorhinolaryngology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania aut Žekonienė Jurgita Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania aut Padervinskis Evaldas Department of Otorhinolaryngology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania aut Žekonis Gediminas Department of Dental and Maxillofacial Orthopedics, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania aut Vaitkus Saulius Department of Otorhinolaryngology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/2(2015-02-01), 271-278 0937-4477 272:2<271 2015 272 405 https://doi.org/10.1007/s00405-014-3023-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3023-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Siupsinskiene Nora Department of Otorhinolaryngology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania aut NATIONALLICENCE 700 1- Žekonienė Jurgita Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania aut NATIONALLICENCE 700 1- Padervinskis Evaldas Department of Otorhinolaryngology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania aut NATIONALLICENCE 700 1- Žekonis Gediminas Department of Dental and Maxillofacial Orthopedics, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania aut NATIONALLICENCE 700 1- Vaitkus Saulius Department of Otorhinolaryngology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/2(2015-02-01), 271-278 0937-4477 272:2<271 2015 272 405