caa a22 4500 606187138 CHVBK 20210128100839.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00405-015-3653-2 doi (NATIONALLICENCE)springer-10.1007/s00405-015-3653-2 Downbeat nystagmus: evidence for enhancement of utriculo-ocular pathways by ocular vestibular evoked myogenic potentials? [Elektronische Daten] [Tatiana Bremova, Stefan Glasauer, Michael Strupp] Downbeat nystagmus (DBN) is caused by an impairment of Purkinje cells in the flocculus. The decreased cerebellar inhibitory input affects otolith pathways. Since ocular and cervical vestibular evoked myogenic potentials (o-/cVEMP) test the otoliths, the VEMP were measured in DBN patients and in controls. Sixteen patients with DBN, 14 cerebellar oculomotor disorder patients without DBN (COMD), and 16 healthy controls were examined with o-/cVEMP. Computational modeling was used to predict VEMP differences between groups. DBN patients had significantly higher oVEMP peak-to-peak (PP) amplitudes than COMD patients without DBN and controls. Cervical VEMP did not differ. The computational model of DBN predicted a twofold oVEMP increase for DBN patients. These findings suggest an enhancement of the utriculo-ocular response. The unchanged cVEMP indicate no effect on the otolith-cervical reflex in DBN. Computational modeling suggests that the utriculo-ocular enhancement is caused by an impaired vertical neural integrator resulting in the increased influence of utricular signals. This also explains the gravitational dependence of DBN. Springer-Verlag Berlin Heidelberg, 2015 Downbeat nystagmus nationallicence Cerebellar degeneration nationallicence oVEMP nationallicence cVEMP nationallicence Vestibular function nationallicence Otolith nationallicence Bremova Tatiana German Center for Vertigo and Balance Disorders, University Hospital Munich, Marchioninistrasse 15, 81377, Munich, Germany aut Glasauer Stefan German Center for Vertigo and Balance Disorders, University Hospital Munich, Marchioninistrasse 15, 81377, Munich, Germany aut Strupp Michael German Center for Vertigo and Balance Disorders, University Hospital Munich, Marchioninistrasse 15, 81377, Munich, Germany aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3575-3583 0937-4477 272:11<3575 2015 272 405 https://doi.org/10.1007/s00405-015-3653-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-015-3653-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bremova Tatiana German Center for Vertigo and Balance Disorders, University Hospital Munich, Marchioninistrasse 15, 81377, Munich, Germany aut NATIONALLICENCE 700 1- Glasauer Stefan German Center for Vertigo and Balance Disorders, University Hospital Munich, Marchioninistrasse 15, 81377, Munich, Germany aut NATIONALLICENCE 700 1- Strupp Michael German Center for Vertigo and Balance Disorders, University Hospital Munich, Marchioninistrasse 15, 81377, Munich, Germany aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3575-3583 0937-4477 272:11<3575 2015 272 405