caa a22 4500 606187154 CHVBK 20210128100839.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00405-014-3396-5 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3396-5 Pathohistological changes of tracheal epithelium in laryngectomized patients [Elektronische Daten] [Marinela Rosso, Drago Prgomet, Ksenija Marjanović, Silvija Pušeljić, Nikola Kraljik] Total laryngectomy results in a permanent disconnection of the upper and lower airways. Thus, the upper airways are bypassed and can no longer condition, humidify, and filter the inhaled air, leading to damage of the tracheobronchial epithelium. There is little scientific information available about the effects of tracheostoma breathing and the degree of mucosal damage in laryngectomized patients. The aims of this study were to determine the histopathologic findings and investigate the potential impact of using a heat and moisture exchanger (HME) on the tracheal epithelium in long-term tracheostomy patients. Tracheal mucosal biopsies were taken from a total of 70 patients. Specimens were stained with hematoxylin and eosin and examined by a light microscope. Normal pseudostratified ciliated columnar epithelium was found in only 9 (12.9%) cases; while, 17 (24.3%) cases had some degree of basal cell hyperplasia. Squamous metaplasia was the most common finding (50%). Pre-invasive lesions (mild and moderate squamous dysplasia) were found in only one patient who used an HME, and in eight (11.4%) non-users. Although the HME cannot completely restore the physiological functions of the upper respiratory track, it delivers a better quality of air to the lower airways and has a positive effect on tracheal mucosa. Springer-Verlag Berlin Heidelberg, 2014 Laryngectomy nationallicence Heat and moisture exchanger nationallicence Pulmonary rehabilitation nationallicence Trachea nationallicence Rosso Marinela Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Center Osijek, J. Huttlera 4, 31 000, Osijek, Croatia aut Prgomet Drago Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Center Zagreb, Zagreb, Croatia aut Marjanović Ksenija Institute for Pathology and Forensic Medicine, University Hospital Center Osijek, Osijek, Croatia aut Pušeljić Silvija Clinic for Pediatrics, University Hospital Center Osijek, Osijek, Croatia aut Kraljik Nikola Institute of Public Health for the Osijek-Baranja County, Osijek, Croatia aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3539-3544 0937-4477 272:11<3539 2015 272 405 https://doi.org/10.1007/s00405-014-3396-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3396-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rosso Marinela Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Center Osijek, J. Huttlera 4, 31 000, Osijek, Croatia aut NATIONALLICENCE 700 1- Prgomet Drago Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Center Zagreb, Zagreb, Croatia aut NATIONALLICENCE 700 1- Marjanović Ksenija Institute for Pathology and Forensic Medicine, University Hospital Center Osijek, Osijek, Croatia aut NATIONALLICENCE 700 1- Pušeljić Silvija Clinic for Pediatrics, University Hospital Center Osijek, Osijek, Croatia aut NATIONALLICENCE 700 1- Kraljik Nikola Institute of Public Health for the Osijek-Baranja County, Osijek, Croatia aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3539-3544 0937-4477 272:11<3539 2015 272 405