caa a22 4500 606187197 CHVBK 20210128100839.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00405-014-3389-4 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3389-4 Response evaluation after chemoradiotherapy for advanced staged oropharyngeal squamous cell carcinoma: a nationwide survey in the Netherlands [Elektronische Daten] [Charlotte Schouten, Otto Hoekstra, C. Leemans, Jonas Castelijns, Remco de Bree] Following failure of chemoradiotherapy (CRT) for advanced staged oropharyngeal squamous cell carcinomas (OPSCC), residual tumor can often be treated successfully with salvage surgery, if detected early. Current clinical practice in the VU University Medical Center is to perform routine response evaluation, i.e., examination under general anesthesia (EUA), 12weeks after treatment. However, in the Netherlands there is no consensus on response evaluation in patients with advanced oropharyngeal cancer. Questionnaire on current clinical practice concerning response evaluation after CRT for advanced OPSCC in all eight head and neck cancer centers of the Dutch Head and Neck Oncology Cooperative Group. The response rate was 100%. Response evaluation was routinely performed with various methods in five institutions (62.5%) and in one institute (12.5%) only if clinical evaluation was difficult. Two centers (25%) did not perform response evaluation. In case of suspicion of residual disease during follow-up, six centers (75%) performed imaging prior to EUA and two centers (25%) only if clinical evaluation was difficult. Diagnostic techniques used prior to EUA were MRI (87.5%), diffusion-weighted MRI (37.5%), 18F-FDG-PET-CT (75-87.5%) and CT (37.5%). This survey shows a substantial variation in the diagnostic policy concerning response evaluation after CRT for advanced OPSCC in the Netherlands. There is a need for guidelines for response evaluation in patients with advanced oropharyngeal cancer. Springer-Verlag Berlin Heidelberg, 2014 Oropharyngeal cancer nationallicence Chemoradiotherapy nationallicence Response evaluation nationallicence 18F-FDG-PET-CT nationallicence DW-MRI nationallicence Examination under general anesthesia nationallicence Schouten Charlotte Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands aut Hoekstra Otto Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands aut Leemans C. Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands aut Castelijns Jonas Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands aut de Bree Remco Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3507-3513 0937-4477 272:11<3507 2015 272 405 https://doi.org/10.1007/s00405-014-3389-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3389-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schouten Charlotte Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Hoekstra Otto Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Leemans C. Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Castelijns Jonas Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- de Bree Remco Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3507-3513 0937-4477 272:11<3507 2015 272 405