caa a22 4500 606187308 CHVBK 20210128100840.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00405-014-3317-7 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3317-7 Progress of hearing loss in neurofibromatosis type 2: implications for future management [Elektronische Daten] [Georgios Kontorinis, Jaya Nichani, Simon Freeman, Scott Rutherford, Samantha Mills, Andrew King, Deborah Mawman, Sue Huson, Martin O'Driscoll, D. Gareth Evans, Simon Lloyd] The objective of this study was to describe changes in hearing over time in patients with neurofibromatosis type 2 (NF2) treated conservatively. A retrospective case review was conducted in a tertiary referral centre. Pure tone audiometry, speech discrimination scores, serviceable hearing (American Academy of Otolaryngology class A or B) and measurement of vestibular schwannoma (VS) size on magnetic resonance imaging were evaluated in 56 patients (89 ears) with NF2 with at least one conservatively managed VS. Over a mean follow-up period of 7years (range 0.8-21years) pure tone average thresholds increased gradually with a mean annual rate of 1.3dB for the right ear (p=0.0003) and 2dB for the left ear (p= 0.0009). Speech discrimination scores dropped with an average annual rate of 1.3 and 0.34% in the right and left ear, respectively. Patients maintained serviceable hearing for an average of 7.6years (range 2.7-19.3years). The average annual VS growth was 0.4mm without any correlation with hearing loss. There was a correlation between patients' age and pure tone threshold increase (p<0.05 for both ears). In this selected population of patients with NF2, hearing threshold increases were very slow. In NF2 patients with indolently behaving tumours, serviceable hearing can be maintained for a significant length of time, making conservative management an attractive option. Springer-Verlag Berlin Heidelberg, 2014 Conservative treatment nationallicence Deafness nationallicence Neurofibromatosis type 2 nationallicence Tumour size nationallicence Vestibular schwannoma nationallicence Watch wait rescan protocol nationallicence Kontorinis Georgios University Department of Otolaryngology, Central Manchester University Hospitals NHS Foundation Trust, M13 9PL, Manchester, UK aut Nichani Jaya University Department of Otolaryngology, Central Manchester University Hospitals NHS Foundation Trust, M13 9PL, Manchester, UK aut Freeman Simon University Department of Otolaryngology, Central Manchester University Hospitals NHS Foundation Trust, M13 9PL, Manchester, UK aut Rutherford Scott Department of Neurosurgery, Salford Royal NHS Foundation Trust, Manchester, UK aut Mills Samantha Department of Neuroradiology, Salford Royal NHS Foundation Trust, Manchester, UK aut King Andrew Department of Neurosurgery, Salford Royal NHS Foundation Trust, Manchester, UK aut Mawman Deborah University Department of Otolaryngology, Central Manchester University Hospitals NHS Foundation Trust, M13 9PL, Manchester, UK aut Huson Sue Department of Genetics Medicine, Central Manchester University Hospitals NHS Foundation Trust, M13 9PL, Manchester, UK aut O'Driscoll Martin University Department of Otolaryngology, Central Manchester University Hospitals NHS Foundation Trust, M13 9PL, Manchester, UK aut Gareth Evans D. Department of Genetics Medicine, Central Manchester University Hospitals NHS Foundation Trust, M13 9PL, Manchester, UK aut Lloyd Simon University Department of Otolaryngology, Central Manchester University Hospitals NHS Foundation Trust, M13 9PL, Manchester, UK aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3143-3150 0937-4477 272:11<3143 2015 272 405 https://doi.org/10.1007/s00405-014-3317-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3317-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kontorinis Georgios University Department of Otolaryngology, Central Manchester University Hospitals NHS Foundation Trust, M13 9PL, Manchester, UK aut NATIONALLICENCE 700 1- Nichani Jaya University Department of Otolaryngology, Central Manchester University Hospitals NHS Foundation Trust, M13 9PL, Manchester, UK aut NATIONALLICENCE 700 1- Freeman Simon University Department of Otolaryngology, Central Manchester University Hospitals NHS Foundation Trust, M13 9PL, Manchester, UK aut NATIONALLICENCE 700 1- Rutherford Scott Department of Neurosurgery, Salford Royal NHS Foundation Trust, Manchester, UK aut NATIONALLICENCE 700 1- Mills Samantha Department of Neuroradiology, Salford Royal NHS Foundation Trust, Manchester, UK aut NATIONALLICENCE 700 1- King Andrew Department of Neurosurgery, Salford Royal NHS Foundation Trust, Manchester, UK aut NATIONALLICENCE 700 1- Mawman Deborah University Department of Otolaryngology, Central Manchester University Hospitals NHS Foundation Trust, M13 9PL, Manchester, UK aut NATIONALLICENCE 700 1- Huson Sue Department of Genetics Medicine, Central Manchester University Hospitals NHS Foundation Trust, M13 9PL, Manchester, UK aut NATIONALLICENCE 700 1- O'Driscoll Martin University Department of Otolaryngology, Central Manchester University Hospitals NHS Foundation Trust, M13 9PL, Manchester, UK aut NATIONALLICENCE 700 1- Gareth Evans D. Department of Genetics Medicine, Central Manchester University Hospitals NHS Foundation Trust, M13 9PL, Manchester, UK aut NATIONALLICENCE 700 1- Lloyd Simon University Department of Otolaryngology, Central Manchester University Hospitals NHS Foundation Trust, M13 9PL, Manchester, UK aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3143-3150 0937-4477 272:11<3143 2015 272 405