caa a22 4500 606187340 CHVBK 20210128100840.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00405-014-3336-4 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3336-4 Effects of heat and moisture exchangers on tracheal mucociliary clearance in laryngectomized patients: a multi-center case-control study [Elektronische Daten] [C. van den Boer, S. Muller, V. van der Noort, R. Olmos, A. Minni, C. Parrilla, F. Hilgers, M. van den Brekel, S. van der Baan] After total laryngectomy, inspired air is no longer optimally conditioned by the upper airways. Impaired mucociliary clearance and histological changes of respiratory epithelium, such as loss of ciliated cells, have been described in laryngectomized patients. Heat and moisture exchangers (HMEs) are passive humidifiers that re-condition the inspired air. Aim of this study was to assess the effect of HMEs on tracheal epithelium and tracheal mucus transport velocity (TMV). Tracheal brush biopsies were collected in three groups of TLE patients: 21 long-term HME users, 10 non-HME users, and 16 non-HME users before and after 4-9months HME use. Tracheal epithelium biopsies were assessed using a digital high-speed camera mounted onto a light microscope. TMV was determined by scintigraphy in the first two patient groups. Significantly more ciliated cells were found in HME users compared to non-HME users (p=0.05). TMV was higher in HME users (median 2mm/min; 0-7.9) compared to non-HME users (median 0.8mm/min; 0-12.3), but this difference was not significant (p=0.37). One-hour breathing without HME in long-term HME users did not measurably decrease TMV (p=0.13). The long-term use of an HME restores/prevents the loss of tracheal ciliated cells. A significant improvement in TMV was not found. Short-term (one hour) detachment of an HME has no measurable effect on TMV. Springer-Verlag Berlin Heidelberg, 2014 Heat and moisture exchanger nationallicence Mucociliary clearance nationallicence Total laryngectomy nationallicence Cilia nationallicence Mucus nationallicence Trachea nationallicence van den Boer C. Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut Muller S. Department of Clinical Physics and Instrumentation, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut van der Noort V. Department of Biometrics, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut Olmos R. Department of Nuclear Medicine, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut Minni A. Department of Otorhinolaryngology and Head and Neck Surgery, La Sapienza Hospital, Viale del Policlinico, 155, 00161, Rome, Italy aut Parrilla C. Department of Otorhinolaryngology and Head and Neck Surgery, Gemelli Hospital, Largo Agostino Gemelli, 8, 00168, Rome, Italy aut Hilgers F. Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut van den Brekel M. Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut van der Baan S. Department of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3439-3450 0937-4477 272:11<3439 2015 272 405 https://doi.org/10.1007/s00405-014-3336-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3336-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van den Boer C. Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Muller S. Department of Clinical Physics and Instrumentation, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van der Noort V. Department of Biometrics, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Olmos R. Department of Nuclear Medicine, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Minni A. Department of Otorhinolaryngology and Head and Neck Surgery, La Sapienza Hospital, Viale del Policlinico, 155, 00161, Rome, Italy aut NATIONALLICENCE 700 1- Parrilla C. Department of Otorhinolaryngology and Head and Neck Surgery, Gemelli Hospital, Largo Agostino Gemelli, 8, 00168, Rome, Italy aut NATIONALLICENCE 700 1- Hilgers F. Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van den Brekel M. Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van der Baan S. Department of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3439-3450 0937-4477 272:11<3439 2015 272 405