caa a22 4500 60618743X CHVBK 20210128100840.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00405-014-3379-6 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3379-6 Prospective clinical study on long-term swallowing function and voice quality in advanced head and neck cancer patients treated with concurrent chemoradiotherapy and preventive swallowing exercises [Elektronische Daten] [Sophie Kraaijenga, Lisette van der Molen, Irene Jacobi, Olga Hamming-Vrieze, Frans Hilgers, Michiel van den Brekel] Concurrent chemoradiotherapy (CCRT) for advanced head and neck cancer (HNC) is associated with substantial early and late side effects, most notably regarding swallowing function, but also regarding voice quality and quality of life (QoL). Despite increased awareness/knowledge on acute dysphagia in HNC survivors, long-term (i.e., beyond 5years) prospectively collected data on objective and subjective treatment-induced functional outcomes (and their impact on QoL) still are scarce. The objective of this study was the assessment of long-term CCRT-induced results on swallowing function and voice quality in advanced HNC patients. The study was conducted as a randomized controlled trial on preventive swallowing rehabilitation (2006-2008) in a tertiary comprehensive HNC center with twenty-two disease-free and evaluable HNC patients as participants. Multidimensional assessment of functional sequels was performed with videofluoroscopy, mouth opening measurements, Functional Oral Intake Scale, acoustic voice parameters, and (study specific, SWAL-QoL, and VHI) questionnaires. Outcome measures at 6years post-treatment were compared with results at baseline and at 2years post-treatment. At a mean follow-up of 6.1years most initial tumor-, and treatment-related problems remained similarly low to those observed after 2years follow-up, except increased xerostomia (68%) and increased (mild) pain (32%). Acoustic voice analysis showed less voicedness, increased fundamental frequency, and more vocal effort for the tumors located below the hyoid bone (n=12), without recovery to baseline values. Patients' subjective vocal function (VHI score) was good. Functional swallowing and voice problems at 6years post-treatment are minimal in this patient cohort, originating from preventive and continued post-treatment rehabilitation programs. Springer-Verlag Berlin Heidelberg, 2014 Head and neck cancer nationallicence Chemoradiotherapy nationallicence Dysphagia nationallicence Swallowing nationallicence Voice nationallicence (Preventive) rehabilitation exercises nationallicence Kraaijenga Sophie Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut van der Molen Lisette Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut Jacobi Irene Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut Hamming-Vrieze Olga Department of Radiation Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut Hilgers Frans Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut van den Brekel Michiel Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3521-3531 0937-4477 272:11<3521 2015 272 405 https://doi.org/10.1007/s00405-014-3379-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3379-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kraaijenga Sophie Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van der Molen Lisette Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Jacobi Irene Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Hamming-Vrieze Olga Department of Radiation Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Hilgers Frans Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van den Brekel Michiel Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3521-3531 0937-4477 272:11<3521 2015 272 405