caa a22 4500 606187472 CHVBK 20210128100840.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00405-014-3294-x doi (NATIONALLICENCE)springer-10.1007/s00405-014-3294-x Vestibular evoked myogenic potential responses in obstructive sleep apnea syndrome [Elektronische Daten] [Murad Mutlu, Ömer Bayır, Melike Yüceege, Tuğba Karagöz, Hikmet Fırat, Ali Özdek, İstemihan Akın, Hakan Korkmaz] Obstructive sleep apnea syndrome (OSAS) provokes oxidative stress and ischemia, which affects the central nervous system. The degeneration of neurons in the brainstem due to periodic hypoxia can be evaluated by vestibular and audiologic tests. The objective of this study is to determine brainstem damage in severe OSAS patients with the help of vestibular evoked myogenic potential (VEMP) responses. Prospective, randomize, double-blind. Research—training hospital. We compared cervical vestibular evoked myogenic potential (cVEMP) responses between severe OSAS patients and a control group. 54 patients were included and divided into the OSAS group, with severe OSAS (apnea-hypopnea index, AHI >70), and a control group with snoring without OSAS (AHI <5). Both groups underwent cVEMP. Bilateral recordings with simultaneous binaural logon stimulations were used during VEMP recordings. The existing p1n1 and n2p2 responses, p1, n1, n2, and p2 latencies and amplitudes, and p1n1 and n2p2 intervals were measured. Statistically significant differences were revealed between patients and controls for the response rate of the p1n1, n2p2 and p1n1, n2p2 amplitudes. There were no significant differences between the two groups with respect to the latencies of p1, n1, n2 and p2, or the p1n1 and n2p2 intervals. The VEMP response rate was lower in severe OSAS patients, and all amplitudes were shorter than in healthy subjects. VEMP recordings in severe OSAS subjects demonstrates abnormalities in brainstem pathways. It appears that brainstem damage in severe OSAS can be detected by cVEMP recordings. Springer-Verlag Berlin Heidelberg, 2014 Obstructive sleep apnea nationallicence Vestibular evoked myogenic potentials nationallicence Brainstem nationallicence Ischemia nationallicence Mutlu Murad Department of Otorhinolaryngology and Head and Neck Surgery, Ministiry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Yeşiltepe 4. Blok D: 61, Emek, 06510, Ankara, Turkey aut Bayır Ömer Department of Otorhinolaryngology and Head and Neck Surgery, Ministiry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Yeşiltepe 4. Blok D: 61, Emek, 06510, Ankara, Turkey aut Yüceege Melike Department of Pulmonary Diseases, Ministiry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Ankara, Turkey aut Karagöz Tuğba Department of Otorhinolaryngology and Head and Neck Surgery, Ministiry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Yeşiltepe 4. Blok D: 61, Emek, 06510, Ankara, Turkey aut Fırat Hikmet Department of Pulmonary Diseases, Ministiry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Ankara, Turkey aut Özdek Ali Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine, Karabük University, Karabük, Turkey aut Akın İstemihan Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine, Kafkas University, Kars, Turkey aut Korkmaz Hakan Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3137-3141 0937-4477 272:11<3137 2015 272 405 https://doi.org/10.1007/s00405-014-3294-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3294-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mutlu Murad Department of Otorhinolaryngology and Head and Neck Surgery, Ministiry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Yeşiltepe 4. Blok D: 61, Emek, 06510, Ankara, Turkey aut NATIONALLICENCE 700 1- Bayır Ömer Department of Otorhinolaryngology and Head and Neck Surgery, Ministiry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Yeşiltepe 4. Blok D: 61, Emek, 06510, Ankara, Turkey aut NATIONALLICENCE 700 1- Yüceege Melike Department of Pulmonary Diseases, Ministiry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Karagöz Tuğba Department of Otorhinolaryngology and Head and Neck Surgery, Ministiry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Yeşiltepe 4. Blok D: 61, Emek, 06510, Ankara, Turkey aut NATIONALLICENCE 700 1- Fırat Hikmet Department of Pulmonary Diseases, Ministiry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Özdek Ali Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine, Karabük University, Karabük, Turkey aut NATIONALLICENCE 700 1- Akın İstemihan Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine, Kafkas University, Kars, Turkey aut NATIONALLICENCE 700 1- Korkmaz Hakan Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3137-3141 0937-4477 272:11<3137 2015 272 405