caa a22 4500 606187480 CHVBK 20210128100841.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00405-014-3369-8 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3369-8 Non-endemic locoregionally advanced nasopharyngeal carcinoma: long-term outcome after induction plus concurrent chemoradiotherapy in everyday clinical practice [Elektronische Daten] [Paolo Boscolo-Rizzo, Giancarlo Tirelli, Monica Mantovani, Vittorio Baggio, Valentina Lupato, Giacomo Spinato, Alessandro Gava, Maria Da Mosto] The aim of this study was to evaluate the long-term outcome in Caucasian population of a non-endemic area treated for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) with multidrug platinum-based induction plus concurrent chemoradiotherapy (IC/CCRT) in everyday clinical practice setting. Between May 1990 and July 2007, 75 patients with newly diagnosed histologically confirmed LA-NPC were given IC/CCRT. All patients were judged suitable to receive conventional fractionated course of radiotherapy to a dose of 70Gy in 35 fractions (2Gy per fraction). The intended chemotherapy regimen consisted in one cycle of induction chemotherapy followed by radiotherapy concomitantly with two cycles of chemotherapy. Each cycle of chemotherapy included cis-platinum, 100mg/m2, and continuous infusion of 5-fluorouracil, 1,000mg/m2/d for 5days. The median follow-up in survivors was 122months. The complete response rate after CCRT was 90.7%. The main limiting toxicity was grade 3 and 4 pharyngeal mucositis (46.7%). Five-year cumulative rate of locoregional control (LRC), distant control (DC), overall survival (OS), and event-free survival (EFS) was 80.1, 82.2, 72.0, and 66.7%, respectively. Ten-year cumulative rate of LRC, DC, OS, and EFS was 73.4, 73.8, 57.1, and 55.2%, respectively. At multivariate analysis advanced N category and low hemoglobin levels at baseline were found to be independent predictors for both worse OS and EFS. In everyday clinical practice, treating LA-NPC with cisplatin-based IC/CCRT was relatively safe and long-term effective. Springer-Verlag Berlin Heidelberg, 2014 Nasopharyngeal carcinoma nationallicence Radiotherapy nationallicence Induction chemotherapy nationallicence Concurrent chemoradiotherapy nationallicence Long-term outcome nationallicence Toxicity nationallicence Boscolo-Rizzo Paolo Department of Neurosciences, ENT Clinic and Regional Center for Head and Neck Cancer, University of Padua, Treviso Regional Hospital, Piazzale Ospedale 1, 31100, Treviso, Italy aut Tirelli Giancarlo Head and Neck Department, University of Trieste, Trieste, Italy aut Mantovani Monica Department of Neurosciences, ENT Clinic and Regional Center for Head and Neck Cancer, University of Padua, Treviso Regional Hospital, Piazzale Ospedale 1, 31100, Treviso, Italy aut Baggio Vittorio Department of Radiation Oncology, Treviso Regional Hospital, Treviso, Italy aut Lupato Valentina Department of Neurosciences, ENT Clinic and Regional Center for Head and Neck Cancer, University of Padua, Treviso Regional Hospital, Piazzale Ospedale 1, 31100, Treviso, Italy aut Spinato Giacomo Head and Neck Department, University of Trieste, Trieste, Italy aut Gava Alessandro Department of Radiation Oncology, Treviso Regional Hospital, Treviso, Italy aut Da Mosto Maria Department of Neurosciences, ENT Clinic and Regional Center for Head and Neck Cancer, University of Padua, Treviso Regional Hospital, Piazzale Ospedale 1, 31100, Treviso, Italy aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3491-3498 0937-4477 272:11<3491 2015 272 405 https://doi.org/10.1007/s00405-014-3369-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3369-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Boscolo-Rizzo Paolo Department of Neurosciences, ENT Clinic and Regional Center for Head and Neck Cancer, University of Padua, Treviso Regional Hospital, Piazzale Ospedale 1, 31100, Treviso, Italy aut NATIONALLICENCE 700 1- Tirelli Giancarlo Head and Neck Department, University of Trieste, Trieste, Italy aut NATIONALLICENCE 700 1- Mantovani Monica Department of Neurosciences, ENT Clinic and Regional Center for Head and Neck Cancer, University of Padua, Treviso Regional Hospital, Piazzale Ospedale 1, 31100, Treviso, Italy aut NATIONALLICENCE 700 1- Baggio Vittorio Department of Radiation Oncology, Treviso Regional Hospital, Treviso, Italy aut NATIONALLICENCE 700 1- Lupato Valentina Department of Neurosciences, ENT Clinic and Regional Center for Head and Neck Cancer, University of Padua, Treviso Regional Hospital, Piazzale Ospedale 1, 31100, Treviso, Italy aut NATIONALLICENCE 700 1- Spinato Giacomo Head and Neck Department, University of Trieste, Trieste, Italy aut NATIONALLICENCE 700 1- Gava Alessandro Department of Radiation Oncology, Treviso Regional Hospital, Treviso, Italy aut NATIONALLICENCE 700 1- Da Mosto Maria Department of Neurosciences, ENT Clinic and Regional Center for Head and Neck Cancer, University of Padua, Treviso Regional Hospital, Piazzale Ospedale 1, 31100, Treviso, Italy aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3491-3498 0937-4477 272:11<3491 2015 272 405