caa a22 4500 606187561 CHVBK 20210128100841.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00405-014-3383-x doi (NATIONALLICENCE)springer-10.1007/s00405-014-3383-x Relaxin-2 expression in temporal bone carcinoma [Elektronische Daten] [Gino Marioni, Elisabetta Zanoletti, Andrea Lovato, Sebastiano Franchella, Luciano Giacomelli, Andrea Gianatti, Antonio Mazzoni, Stella Blandamura, Alessandro Martini] Temporal bone squamous cell carcinoma (TBSCC) is an uncommon, aggressive malignancy with a significant local recurrence rate even in patients with postoperative pathology reports of free surgical margins. This raises the question of how "free” negative margins should be to be oncologically safe, especially in bone tissue. A potential role for relaxin-2 hormone in tumor-driven osteolysis has recently been reported. The aim of this study was to assess the prognostic role of relaxin-2 expression in TBSCC tissue specimens and pathologically negative bone margins. Relaxin-2 immunohistochemical expression was assessed in 25 consecutively operated TBSCC patients. Several pathological variables correlated with recurrence rate (pT stage, dura mater involvement), disease-free survival (DFS) (pT stage, pN status, grade, and dura mater involvement), and disease-specific survival (DSS) (pT stage, pN status, grade, and dura mater involvement). The recurrence rate, DFS, and DSS did not correlate with relaxin-2 expression in TBSCC specimens or pathologically negative bone margins. Although local recurrence in TBSCC could relate to neoplastic bone invasion not apparent on conventional pathological investigations, the present preliminary findings seem to rule out any role of relaxin-2 in mediating this local aggressiveness. Molecular mechanisms of TBSCC recurrence after curative treatment should be further investigated. Springer-Verlag Berlin Heidelberg, 2014 Temporal bone squamous cell carcinoma nationallicence Relaxin-2 nationallicence Bone invasion nationallicence Prognosis nationallicence Marioni Gino Department of Neurosciences, Otolaryngology Section, University of Padova, Via Giustiniani 2, 35128, Padova, Italy aut Zanoletti Elisabetta Department of Neurosciences, Otolaryngology Section, University of Padova, Via Giustiniani 2, 35128, Padova, Italy aut Lovato Andrea Department of Neurosciences, Otolaryngology Section, University of Padova, Via Giustiniani 2, 35128, Padova, Italy aut Franchella Sebastiano Department of Neurosciences, Otolaryngology Section, University of Padova, Via Giustiniani 2, 35128, Padova, Italy aut Giacomelli Luciano DIMED, University of Padova, Padova, Italy aut Gianatti Andrea Anatomic Pathology Unit, Ospedali Riuniti Bergamo, Bergamo, Italy aut Mazzoni Antonio Department of Neurosciences, Otolaryngology Section, University of Padova, Via Giustiniani 2, 35128, Padova, Italy aut Blandamura Stella DIMED, University of Padova, Padova, Italy aut Martini Alessandro Department of Neurosciences, Otolaryngology Section, University of Padova, Via Giustiniani 2, 35128, Padova, Italy aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3225-3232 0937-4477 272:11<3225 2015 272 405 https://doi.org/10.1007/s00405-014-3383-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3383-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Marioni Gino Department of Neurosciences, Otolaryngology Section, University of Padova, Via Giustiniani 2, 35128, Padova, Italy aut NATIONALLICENCE 700 1- Zanoletti Elisabetta Department of Neurosciences, Otolaryngology Section, University of Padova, Via Giustiniani 2, 35128, Padova, Italy aut NATIONALLICENCE 700 1- Lovato Andrea Department of Neurosciences, Otolaryngology Section, University of Padova, Via Giustiniani 2, 35128, Padova, Italy aut NATIONALLICENCE 700 1- Franchella Sebastiano Department of Neurosciences, Otolaryngology Section, University of Padova, Via Giustiniani 2, 35128, Padova, Italy aut NATIONALLICENCE 700 1- Giacomelli Luciano DIMED, University of Padova, Padova, Italy aut NATIONALLICENCE 700 1- Gianatti Andrea Anatomic Pathology Unit, Ospedali Riuniti Bergamo, Bergamo, Italy aut NATIONALLICENCE 700 1- Mazzoni Antonio Department of Neurosciences, Otolaryngology Section, University of Padova, Via Giustiniani 2, 35128, Padova, Italy aut NATIONALLICENCE 700 1- Blandamura Stella DIMED, University of Padova, Padova, Italy aut NATIONALLICENCE 700 1- Martini Alessandro Department of Neurosciences, Otolaryngology Section, University of Padova, Via Giustiniani 2, 35128, Padova, Italy aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3225-3232 0937-4477 272:11<3225 2015 272 405