caa a22 4500 60618760X CHVBK 20210128100841.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00405-014-3456-x doi (NATIONALLICENCE)springer-10.1007/s00405-014-3456-x Endoglin (CD105) expression in sinonasal polyposis [Elektronische Daten] [Giancarlo Ottaviano, Rocco Cappellesso, Ioannis Mylonakis, Marco Lionello, Niccolò Favaretto, Luciano Giacomelli, Cristiano Spoladore, Rosario Marchese-Ragona, Filippo Marino, Alberto Staffieri, Alessandro Martini, Gino Marioni] Despite appropriate surgical therapy, 5-10% of patients with chronic rhinosinusitis (CRS) and nasal polyps (NP) experience disease recurrences. It has been suggested that angiogenesis may relate to the pathogenesis and prognosis of CRS with NP. Endoglin (CD105) is a component of the receptor complex of transforming growth factor-beta, a pleiotropic cytokine that modulates angiogenesis. A series of patients treated surgically for CRS with NP was analyzed to assess the relationship between CD105 expression, main clinicopathological features, and recurrence rate. The immunohistochemical expression of CD105 was assessed in 70 patients consecutively operated for CRS with NP. In the univariate setting, the presence of CD105 (1/0) showed a trend towards a significant association with increasing NP dimensions (p=0.054). Intensity of CD105 reaction was also significantly associated with NP size (0.04) and with an eosinophilic histology (p=0.048). In our multivariate setting, only asthma (p=0.016), hypereosinophilia (p=0.022), and preoperative polyposis score (p=0.046) retained their independent prognostic significance in relation to NP recurrence. Further efforts are needed to elucidate the biological, angiogenic and proliferative mechanisms behind recurrent NP. Our preliminary results support the clinical utility of extra postoperative care, in terms of closer follow-ups and medication with oral anti-histamines, topical and/or oral steroids, and antileukotrienes in patients with asthma, advanced nasal polyposis at presentation, and serum hypereosinophilia. Springer-Verlag Berlin Heidelberg, 2015 Nasal polyposis nationallicence Surgery nationallicence Nasal polyps relapse nationallicence CD105 nationallicence Ottaviano Giancarlo Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy aut Cappellesso Rocco Department of Medicine DIMED, Padova University, Padua, Italy aut Mylonakis Ioannis Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy aut Lionello Marco Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy aut Favaretto Niccolò Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy aut Giacomelli Luciano Department of Medicine DIMED, Padova University, Padua, Italy aut Spoladore Cristiano Department of Medicine DIMED, Padova University, Padua, Italy aut Marchese-Ragona Rosario Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy aut Marino Filippo Department of Medicine DIMED, Padova University, Padua, Italy aut Staffieri Alberto Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy aut Martini Alessandro Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy aut Marioni Gino Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3367-3373 0937-4477 272:11<3367 2015 272 405 https://doi.org/10.1007/s00405-014-3456-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3456-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ottaviano Giancarlo Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy aut NATIONALLICENCE 700 1- Cappellesso Rocco Department of Medicine DIMED, Padova University, Padua, Italy aut NATIONALLICENCE 700 1- Mylonakis Ioannis Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy aut NATIONALLICENCE 700 1- Lionello Marco Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy aut NATIONALLICENCE 700 1- Favaretto Niccolò Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy aut NATIONALLICENCE 700 1- Giacomelli Luciano Department of Medicine DIMED, Padova University, Padua, Italy aut NATIONALLICENCE 700 1- Spoladore Cristiano Department of Medicine DIMED, Padova University, Padua, Italy aut NATIONALLICENCE 700 1- Marchese-Ragona Rosario Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy aut NATIONALLICENCE 700 1- Marino Filippo Department of Medicine DIMED, Padova University, Padua, Italy aut NATIONALLICENCE 700 1- Staffieri Alberto Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy aut NATIONALLICENCE 700 1- Martini Alessandro Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy aut NATIONALLICENCE 700 1- Marioni Gino Otolaryngology Section, Department of Neurosciences, Padova University, Via Giustiniani 2, 35100, Padua, Italy aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3367-3373 0937-4477 272:11<3367 2015 272 405