caa a22 4500 606187685 CHVBK 20210128100841.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00405-014-3310-1 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3310-1 Elderly patients at higher risk of laryngeal carcinoma recurrence could be identified by a panel of two biomarkers (nm23-H1 and CD105) and pN+ status [Elektronische Daten] [Andrea Lovato, Gino Marioni, Enzo Manzato, Claudia Staffieri, Luciano Giacomelli, Giovanni Ralli, Alberto Staffieri, Stella Blandamura] Laryngeal squamous cell carcinoma (LSCC) recurrences are very difficult to manage in elderly patients (age ≥65years), because treatment carries significant morbidity and mortality. The aim of this study was to develop a panel of parameters (clinicopathological variables or biomarkers) to improve our ability to detect elderly patients at higher risk of LSCC recurrence. Maspin, nm23-H1, and CD105 were investigated using immunohistochemistry on surgical specimens from 46 elderly patients treated for LSCC. After univariate analysis identified parameters associated with LSCC recurrence, a multivariate prognostic model was constructed. At univariate analysis, a higher recurrence rate was significantly associated with nm23-H1 nuclear expression in carcinoma cells ≤2.0% (p=0.01), CD105 expression in intratumoral vascular endothelial cells ≥5.28% (p=0.04), and pN+ status (p=0.04). Multivariate modeling confirmed that nuclear nm23-H1 ≤2.0% (p=0.009) and CD105 ≥5.28% (p=0.013) had a negative prognostic significance in terms of disease recurrence, while pN+ status showed a trend toward significance (p=0.05). We thus obtained a panel comprising two biomarkers and neck lymph node status that revealed an excellent discriminatory power [AUC (ROC) of 0.81] in terms of the risk of LSCC recurrence. The panel achieved a specificity of 96% and a positive predictive value of 93%. We identified a panel with an excellent discriminatory power in identifying elderly patients at higher risk of recurrence after treatment for LSCC. These patients would benefit from a more aggressive primary treatment. Springer-Verlag Berlin Heidelberg, 2014 Laryngeal carcinoma nationallicence Elderly nationallicence Prognosis nationallicence Panel nationallicence Biomarkers nationallicence Lovato Andrea Otolaryngology Section, Department of Neurosciences, University of Padova, Via Giustiniani 2, 35128, Padua, Italy aut Marioni Gino Otolaryngology Section, Department of Neurosciences, University of Padova, Via Giustiniani 2, 35128, Padua, Italy aut Manzato Enzo Department of Medicine DIMED, University of Padova, Padua, Italy aut Staffieri Claudia Otolaryngology Section, Department of Neurosciences, Treviso Hospital Branch, University of Padova, Padua, Italy aut Giacomelli Luciano Department of Medicine DIMED, University of Padova, Padua, Italy aut Ralli Giovanni ENT Department, University of Rome "La Sapienza”, Rome, Italy aut Staffieri Alberto Otolaryngology Section, Department of Neurosciences, University of Padova, Via Giustiniani 2, 35128, Padua, Italy aut Blandamura Stella Department of Medicine DIMED, University of Padova, Padua, Italy aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3417-3424 0937-4477 272:11<3417 2015 272 405 https://doi.org/10.1007/s00405-014-3310-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3310-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lovato Andrea Otolaryngology Section, Department of Neurosciences, University of Padova, Via Giustiniani 2, 35128, Padua, Italy aut NATIONALLICENCE 700 1- Marioni Gino Otolaryngology Section, Department of Neurosciences, University of Padova, Via Giustiniani 2, 35128, Padua, Italy aut NATIONALLICENCE 700 1- Manzato Enzo Department of Medicine DIMED, University of Padova, Padua, Italy aut NATIONALLICENCE 700 1- Staffieri Claudia Otolaryngology Section, Department of Neurosciences, Treviso Hospital Branch, University of Padova, Padua, Italy aut NATIONALLICENCE 700 1- Giacomelli Luciano Department of Medicine DIMED, University of Padova, Padua, Italy aut NATIONALLICENCE 700 1- Ralli Giovanni ENT Department, University of Rome "La Sapienza”, Rome, Italy aut NATIONALLICENCE 700 1- Staffieri Alberto Otolaryngology Section, Department of Neurosciences, University of Padova, Via Giustiniani 2, 35128, Padua, Italy aut NATIONALLICENCE 700 1- Blandamura Stella Department of Medicine DIMED, University of Padova, Padua, Italy aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3417-3424 0937-4477 272:11<3417 2015 272 405