caa a22 4500 606187693 CHVBK 20210128100841.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00405-014-3446-z doi (NATIONALLICENCE)springer-10.1007/s00405-014-3446-z Nasal endoscopy and paranasal sinus computerised tomography (CT) findings in an Irish cystic fibrosis adult patient group [Elektronische Daten] [P. Casserly, M. Harrison, O. O'Connell, N. O'Donovan, B. Plant, P. O'Sullivan] Cystic fibrosis (CF) is a common inherited disorder in Caucasians in Ireland having the highest reported incidence. CF has well-recognised clinical sequelae in several physiological systems. Its' impact on the sinonasal system is less well established. We evaluated symptoms, endoscopic and computerised tomographic (CT) findings in an Irish adult CF group with the aim of characterising the relationship between these clinical features in an Irish CF group. Adult CF patients attending a specialist clinic underwent prospective evaluation of sinonasal symptoms using a specifically designed questionnaire. They subsequently underwent nasoendoscopy and CT scanning of their paranasal sinuses. Abnormalities identified were quantified using established radiological (Lund-Mackay) and endoscopic (Lund-Kennedy) scoring systems. The relationship between symptoms of chronic rhinosinusitis (CRS), endoscopic findings and CT abnormalities were then compared. Sixty-three CF patients (n=63) were studied. 29 patients had a CT scan. Thirty-three CF patients (52%) had no symptoms of CRS. Fifty CF patients (80% of CF group) had evidence of CRS on nasoendoscopy including thirteen patients (20%) with nasal polyposis. 98% of patients scanned have positive findings on CT scan. There was no significant difference between symptomatic and asymptomatic CF groups with respect to their Lund-Kennedy endoscopic score or their Lund-Mackay CT score. 86% demonstrated one or more hypoplastic sinus. There was no increased incidence of hypoplastic sinuses amongst Δf508 homozygotes than other mutation groups. Springer-Verlag Berlin Heidelberg, 2014 Cystic fibrosis nationallicence Chronic rhinosinusitis nationallicence Sinus hypoplasia nationallicence CT sinuses nationallicence Nasoendoscopy nationallicence CF class mutation nationallicence Casserly P. Department of Otolaryngology, South Infirmary Victoria University Hospital, Cork, Republic of Ireland aut Harrison M. Cork Adult Cystic Fibrosis Centre, University College Cork, Cork University Hospital, Cork, Ireland aut O'Connell O. Cork Adult Cystic Fibrosis Centre, University College Cork, Cork University Hospital, Cork, Ireland aut O'Donovan N. Department of Radiology, South Infirmary Victoria University Hospital, Cork, Ireland aut Plant B. Cork Adult Cystic Fibrosis Centre, University College Cork, Cork University Hospital, Cork, Ireland aut O'Sullivan P. Department of Otolaryngology, South Infirmary Victoria University Hospital, Cork, Republic of Ireland aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3353-3359 0937-4477 272:11<3353 2015 272 405 https://doi.org/10.1007/s00405-014-3446-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3446-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Casserly P. Department of Otolaryngology, South Infirmary Victoria University Hospital, Cork, Republic of Ireland aut NATIONALLICENCE 700 1- Harrison M. Cork Adult Cystic Fibrosis Centre, University College Cork, Cork University Hospital, Cork, Ireland aut NATIONALLICENCE 700 1- O'Connell O. Cork Adult Cystic Fibrosis Centre, University College Cork, Cork University Hospital, Cork, Ireland aut NATIONALLICENCE 700 1- O'Donovan N. Department of Radiology, South Infirmary Victoria University Hospital, Cork, Ireland aut NATIONALLICENCE 700 1- Plant B. Cork Adult Cystic Fibrosis Centre, University College Cork, Cork University Hospital, Cork, Ireland aut NATIONALLICENCE 700 1- O'Sullivan P. Department of Otolaryngology, South Infirmary Victoria University Hospital, Cork, Republic of Ireland aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/11(2015-11-01), 3353-3359 0937-4477 272:11<3353 2015 272 405