caa a22 4500 606190422 CHVBK 20210128100855.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s10577-015-9490-8 doi (NATIONALLICENCE)springer-10.1007/s10577-015-9490-8 Transposable elements and early evolution of sex chromosomes in fish [Elektronische Daten] [Domitille Chalopin, Jean-Nicolas Volff, Delphine Galiana, Jennifer Anderson, Manfred Schartl] In many organisms, the sex chromosome pair can be recognized due to heteromorphy; the Y and W chromosomes have often lost many genes due to the absence of recombination during meiosis and are frequently heterochromatic. Repetitive sequences are found at a high proportion on such heterochromatic sex chromosomes and the evolution and emergence of sex chromosomes has been connected to the dynamics of repeats and transposable elements. With an amazing plasticity of sex determination mechanisms and numerous instances of independent emergence of novel sex chromosomes, fish represent an excellent lineage to investigate the early stages of sex chromosome differentiation, where sex chromosomes often are homomorphic and not heterochromatic. We have analyzed the composition, distribution, and relative age of TEs from available sex chromosome sequences of seven teleost fish. We observed recent bursts of TEs and simple repeat accumulations around young sex determination loci. More strikingly, we detected transposable element (TE) amplifications not only on the sex determination regions of the Y and W sex chromosomes, but also on the corresponding regions of the X and Z chromosomes. In one species, we also clearly demonstrated that the observed TE-rich sex determination locus originated from a TE-poor genomic region, strengthening the link between TE accumulation and emergence of the sex determination locus. Altogether, our results highlight the role of TEs in the initial steps of differentiation and evolution of sex chromosomes. Springer Science+Business Media Dordrecht, 2015 Sex chromosomes nationallicence Transposable elements nationallicence Fish nationallicence BAC : Bacterial artificial chromosome nationallicence bp : Base pair nationallicence Chr : Chromosome nationallicence ERV : Endogenous retrovirus nationallicence GSD : Genetic sex determination nationallicence LINE (or SINE) : Long (or short) interspersed nuclear element nationallicence LG : Linkage group nationallicence LTR : Long terminal repeats nationallicence Mb (or kb) : Mega bases (or kilobases) nationallicence Myr : Million years nationallicence nt : Nucleotides nationallicence PAR : Pseudo-autosomal regions nationallicence SD : Sex determination nationallicence SNP : Single nucleotide polymorphism nationallicence TEs : Transposable elements nationallicence TIR : Terminal inverted repeat nationallicence X SD region : Sex-determining region of the X chromosome nationallicence Y SD region : Sex-determining region of the Y chromosome nationallicence Chalopin Domitille Institut de Génomique Fonctionnelle de Lyon, CNRS UMR5242, Ecole Normale Supérieure de Lyon, Lyon, France aut Volff Jean-Nicolas Institut de Génomique Fonctionnelle de Lyon, CNRS UMR5242, Ecole Normale Supérieure de Lyon, Lyon, France aut Galiana Delphine Institut de Génomique Fonctionnelle de Lyon, CNRS UMR5242, Ecole Normale Supérieure de Lyon, Lyon, France aut Anderson Jennifer INRA, Fish Physiology and Genomics (UR1037), Campus de Beaulieu, Rennes, France aut Schartl Manfred Department Physiological Chemistry, Biozentrum, University of Wuerzburg, and Comprehensive Cancer Center Mainfranken, University Clinic Wuerzburg, Wuerzburg, Germany aut Chromosome Research Springer Netherlands 23/3(2015-09-01), 545-560 0967-3849 23:3<545 2015 23 10577 https://doi.org/10.1007/s10577-015-9490-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10577-015-9490-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chalopin Domitille Institut de Génomique Fonctionnelle de Lyon, CNRS UMR5242, Ecole Normale Supérieure de Lyon, Lyon, France aut NATIONALLICENCE 700 1- Volff Jean-Nicolas Institut de Génomique Fonctionnelle de Lyon, CNRS UMR5242, Ecole Normale Supérieure de Lyon, Lyon, France aut NATIONALLICENCE 700 1- Galiana Delphine Institut de Génomique Fonctionnelle de Lyon, CNRS UMR5242, Ecole Normale Supérieure de Lyon, Lyon, France aut NATIONALLICENCE 700 1- Anderson Jennifer INRA, Fish Physiology and Genomics (UR1037), Campus de Beaulieu, Rennes, France aut NATIONALLICENCE 700 1- Schartl Manfred Department Physiological Chemistry, Biozentrum, University of Wuerzburg, and Comprehensive Cancer Center Mainfranken, University Clinic Wuerzburg, Wuerzburg, Germany aut NATIONALLICENCE 773 0- Chromosome Research Springer Netherlands 23/3(2015-09-01), 545-560 0967-3849 23:3<545 2015 23 10577