caa a22 4500 606190473 CHVBK 20210128100855.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s10577-015-9494-4 doi (NATIONALLICENCE)springer-10.1007/s10577-015-9494-4 Transcription of tandemly repetitive DNA: functional roles [Elektronische Daten] [Maria Biscotti, Adriana Canapa, Mariko Forconi, Ettore Olmo, Marco Barucca] A considerable fraction of the eukaryotic genome is made up of satellite DNA constituted of tandemly repeated sequences. These elements are mainly located at centromeres, pericentromeres, and telomeres and are major components of constitutive heterochromatin. Although originally satellite DNA was thought silent and inert, an increasing number of studies are providing evidence on its transcriptional activity supporting, on the contrary, an unexpected dynamicity. This review summarizes the multiple structural roles of satellite noncoding RNAs at chromosome level. Indeed, satellite noncoding RNAs play a role in the establishment of a heterochromatic state at centromere and telomere. These highly condensed structures are indispensable to preserve chromosome integrity and genome stability, preventing recombination events, and ensuring the correct chromosome pairing and segregation. Moreover, these RNA molecules seem to be involved also in maintaining centromere identity and in elongation, capping, and replication of telomere. Finally, the abnormal variation of centromeric and pericentromeric DNA transcription across major eukaryotic lineages in stress condition and disease has evidenced the critical role that these transcripts may play and the potentially dire consequences for the organism. Springer Science+Business Media Dordrecht, 2015 Satellite DNA nationallicence Pericentromeric transcription nationallicence Centromeric transcription nationallicence Telomeric transcription nationallicence Centromere nationallicence Telomere nationallicence Heterochromatin nationallicence Noncoding RNA nationallicence TERRA nationallicence ATRX : Alpha thalassemia/mental retardation syndrome X-linked protein nationallicence BRG1 : Brahma-related gene 1 nationallicence CENP : Centromeric protein nationallicence Chp1 : Chromodomain protein 1 nationallicence DKC1 : Dyskerin nationallicence CLRC : Clr4-Rik1-Cul4 complex nationallicence CPC : Chromosomal passenger complex nationallicence CTCF : Chromatin organizing factor nationallicence dsRNA : Double-stranded RNA nationallicence Exo 1 : Exonuclease 1 nationallicence HAC : Human artificial chromosome nationallicence hnRPA1 : Heterogeneous nuclear ribonucleoprotein A1 nationallicence HOR : High-order repeat nationallicence HP1 : Heterochromatin protein-1 nationallicence HSF1 : Heat shock factor 1 nationallicence H3 : Histone H3 nationallicence ICF : Immunodeficiency, centromere instability, and human facial anomalies syndrome nationallicence INCENP : Inner centromere protein nationallicence lncRNA : Long noncoding RNA nationallicence LncRNA-TAREs : Long telomere-associated noncoding RNAs nationallicence ncRNA : Noncoding RNA nationallicence NS : Nucleostemin nationallicence nSB : Nuclear stress body nationallicence ORC : Origin recognition complex nationallicence Paf1C : Polymerase-associated factor1 complex nationallicence RDRC : RNA-directed RNA polymerase complex nationallicence RdRP : RNA-directed RNA polymearse nationallicence RISC : RNA-induced silencing complex nationallicence RITS : RNA-induced initiation of transcriptional gene silencing nationallicence RNAi : RNA interference nationallicence RNAPol II : RNA polymerase II nationallicence RPA : Replication protein A nationallicence satDNA : Satellite DNA nationallicence siRNA : Small interfering RNA nationallicence Tas3 : Targeting complex subunit 3 nationallicence TCAB1 : Telomerase Cajal body protein 1 nationallicence TER : Telomerase template RNA nationallicence TERRA : Telomeric repeat-containing RNA nationallicence TERT : Telomerase reverse transcriptase nationallicence TPE : Telomere position effect nationallicence T-Recs : Telomerase recruitment clusters nationallicence WDHD1 : WD repeat and HMG-box DNA binding protein 1 nationallicence Biscotti Maria Dipartimento di Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, via Brecce Bianche, 60131, Ancona, Italy aut Canapa Adriana Dipartimento di Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, via Brecce Bianche, 60131, Ancona, Italy aut Forconi Mariko Dipartimento di Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, via Brecce Bianche, 60131, Ancona, Italy aut Olmo Ettore Dipartimento di Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, via Brecce Bianche, 60131, Ancona, Italy aut Barucca Marco Dipartimento di Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, via Brecce Bianche, 60131, Ancona, Italy aut Chromosome Research Springer Netherlands 23/3(2015-09-01), 463-477 0967-3849 23:3<463 2015 23 10577 https://doi.org/10.1007/s10577-015-9494-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10577-015-9494-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Biscotti Maria Dipartimento di Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, via Brecce Bianche, 60131, Ancona, Italy aut NATIONALLICENCE 700 1- Canapa Adriana Dipartimento di Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, via Brecce Bianche, 60131, Ancona, Italy aut NATIONALLICENCE 700 1- Forconi Mariko Dipartimento di Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, via Brecce Bianche, 60131, Ancona, Italy aut NATIONALLICENCE 700 1- Olmo Ettore Dipartimento di Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, via Brecce Bianche, 60131, Ancona, Italy aut NATIONALLICENCE 700 1- Barucca Marco Dipartimento di Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, via Brecce Bianche, 60131, Ancona, Italy aut NATIONALLICENCE 773 0- Chromosome Research Springer Netherlands 23/3(2015-09-01), 463-477 0967-3849 23:3<463 2015 23 10577