caa a22 4500 606190503 CHVBK 20210128100855.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s10577-015-9482-8 doi (NATIONALLICENCE)springer-10.1007/s10577-015-9482-8 Satellite non-coding RNAs: the emerging players in cells, cellular pathways and cancer [Elektronische Daten] [Daniela Ferreira, Susana Meles, Ana Escudeiro, Ana Mendes-da-Silva, Filomena Adega, Raquel Chaves] For several decades, transcriptional inactivity was considered as one of the particular features of constitutive heterochromatin and, therefore, of its major component, satellite DNA sequences. However, more recently, succeeding evidences have demonstrated that these sequences can indeed be transcribed, yielding satellite non-coding RNAs with important roles in the organization and regulation of genomes. Since then, several studies have been conducted, trying to understand the function(s) of these sequences not only in the normal but also in cancer genomes. It is thought that the association between cancer and satncRNAs is mostly due to the influence of these transcripts in the genome instability, a hallmark of cancer. The few reports on satellite DNA transcription in cancer contexts point to its overexpression; however, this scenario may be far more complex, variable, and influenced by a number of factors andthe exact role of satncRNAs in the oncogenic process remains poorly understood. The greater is the knowledge on the association of satncRNAs with cancer, the greater would be the opportunity to assist cancer treatment, either by the design of effective therapies targeting these molecules or by using them as biomarkers in cancer diagnosis, prognosis, and with predictive value. Springer Science+Business Media Dordrecht, 2015 Satellite DNA nationallicence Satellite non-coding RNA nationallicence Cancer nationallicence Biomarkers nationallicence Genomic instability nationallicence ChIP : Chromatin immunoprecipitation nationallicence CPC : Chromosome passenger complex nationallicence CT : Centromeric nationallicence dTALEs : Designer transcription activator-like effectors nationallicence HP1 : Heterochromatin protein 1 nationallicence HSF1 : Heat shock factor 1 nationallicence lncRNAs : Long non-coding RNAs nationallicence mRNAs : Messenger RNAs nationallicence ncRNAs : Non-coding RNAs nationallicence ORF : Open reading frame nationallicence PCT : Pericentromeric nationallicence RIP : RNA immunoprecipitation nationallicence RNA-FISH : RNA fluorescence in situ hybridization nationallicence RT-qPCR : Reverse transcriptase quantitative polymerase chain reaction nationallicence satDNA : Satellite DNA nationallicence satncRNAs : Satellite non-coding RNAs nationallicence siRNAs : Small interfering RNAs nationallicence TonEBF : Tonicity enhancer-binding protein nationallicence TRAIN : Transcription of repeats activates interferon nationallicence Ferreira Daniela Laboratory of Cytogenomics and Animal Genomics (CAG), Department of Genetics and Biotechnology (DGB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal aut Meles Susana Laboratory of Cytogenomics and Animal Genomics (CAG), Department of Genetics and Biotechnology (DGB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal aut Escudeiro Ana Laboratory of Cytogenomics and Animal Genomics (CAG), Department of Genetics and Biotechnology (DGB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal aut Mendes-da-Silva Ana Laboratory of Cytogenomics and Animal Genomics (CAG), Department of Genetics and Biotechnology (DGB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal aut Adega Filomena Laboratory of Cytogenomics and Animal Genomics (CAG), Department of Genetics and Biotechnology (DGB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal aut Chaves Raquel Laboratory of Cytogenomics and Animal Genomics (CAG), Department of Genetics and Biotechnology (DGB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal aut Chromosome Research Springer Netherlands 23/3(2015-09-01), 479-493 0967-3849 23:3<479 2015 23 10577 https://doi.org/10.1007/s10577-015-9482-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10577-015-9482-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ferreira Daniela Laboratory of Cytogenomics and Animal Genomics (CAG), Department of Genetics and Biotechnology (DGB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal aut NATIONALLICENCE 700 1- Meles Susana Laboratory of Cytogenomics and Animal Genomics (CAG), Department of Genetics and Biotechnology (DGB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal aut NATIONALLICENCE 700 1- Escudeiro Ana Laboratory of Cytogenomics and Animal Genomics (CAG), Department of Genetics and Biotechnology (DGB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal aut NATIONALLICENCE 700 1- Mendes-da-Silva Ana Laboratory of Cytogenomics and Animal Genomics (CAG), Department of Genetics and Biotechnology (DGB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal aut NATIONALLICENCE 700 1- Adega Filomena Laboratory of Cytogenomics and Animal Genomics (CAG), Department of Genetics and Biotechnology (DGB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal aut NATIONALLICENCE 700 1- Chaves Raquel Laboratory of Cytogenomics and Animal Genomics (CAG), Department of Genetics and Biotechnology (DGB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal aut NATIONALLICENCE 773 0- Chromosome Research Springer Netherlands 23/3(2015-09-01), 479-493 0967-3849 23:3<479 2015 23 10577