caa a22 4500 606191054 CHVBK 20210128105228.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00391-015-0928-6 doi (NATIONALLICENCE)springer-10.1007/s00391-015-0928-6 Stress and biological aging [Elektronische Daten] A double-edged sword [Andreas Simm, Lars-Oliver Klotz] Stress und biologisches Altern Ein zweischneidiges Schwert It is well accepted that aging is the basis of most degenerative diseases in the elderly. Biological aging is characterized by a gradual accumulation of cellular and molecular defects. An important cause of defects is intense stress, such as oxidative or glycotoxic stress. Genes affecting cellular and organismal longevity are frequently associated with the regulation of cellular anti-oxidative defense and/or with repair functions. Damage, combined with an age-dependent decline in defense and repair systems, results in disturbed homeostasis, leading to aging and diseases. Whereas intense stress induces premature aging, mild stress can induce adaptive processes, stimulating the expression of genetic repair/defense systems, which positively influences life span. Springer-Verlag Berlin Heidelberg, 2015 Oxidative stress nationallicence Advanced glycation end products nationallicence Hormesis nationallicence Forkhead transcription factors nationallicence Glutathione peroxidase nationallicence Oxidativer Stress nationallicence Fortgeschrittene Glykierungsendprodukte nationallicence Hormese nationallicence FoxO-Transkriptionsfaktoren nationallicence Glutathionperoxidase nationallicence Simm Andreas Heart Centre of the University Hospital Halle (Saale), Martin-Luther University Halle-Wittenberg, Ernst-Grube Str. 40, 06120, Halle (Saale), Germany aut Klotz Lars-Oliver Department of Nutrigenomics, Institute of Nutrition, Friedrich-Schiller University Jena, Dornburger Straße 29, 07743, Jena, Germany aut Zeitschrift für Gerontologie und Geriatrie Springer Berlin Heidelberg 48/6(2015-08-01), 505-510 0948-6704 48:6<505 2015 48 391 https://doi.org/10.1007/s00391-015-0928-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00391-015-0928-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Simm Andreas Heart Centre of the University Hospital Halle (Saale), Martin-Luther University Halle-Wittenberg, Ernst-Grube Str. 40, 06120, Halle (Saale), Germany aut NATIONALLICENCE 700 1- Klotz Lars-Oliver Department of Nutrigenomics, Institute of Nutrition, Friedrich-Schiller University Jena, Dornburger Straße 29, 07743, Jena, Germany aut NATIONALLICENCE 773 0- Zeitschrift für Gerontologie und Geriatrie Springer Berlin Heidelberg 48/6(2015-08-01), 505-510 0948-6704 48:6<505 2015 48 391 SWISSBIB 342459007