caa a22 4500 606191097 CHVBK 20210128100858.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00391-014-0843-2 doi (NATIONALLICENCE)springer-10.1007/s00391-014-0843-2 Parameters of bone health and fracture risk in older female fall victims: what do they tell us? [Elektronische Daten] [Heinrich W. Thaler, Christian Oudshoorn, Klaas A. Hartholt, Tischa J.M. van der Cammen] Sturz und Fraktur - Gibt es aussagekräftige serologische "Knochenparameter" bezüglich des Frakturrisikos bei älteren Patientinnen? Introduction: A common and severe osteoporotic type fracture in older women is a hip fracture. It is not clear whether bone turnover parameters measured in blood can be a useful tool to predict fracture risk in older persons. The aim of the current study was to assess the association between serum vitamin D (25OHD) levels, parathyroid hormone (PTH), total osteocalcin, carboxy-terminal collagen crosslinks (CTX) and hip fractures in older fallers. Material and methods: A single centre, prospective cohort study of bone parameters was carried out in 400 female patients aged > 70 years including 200 with a hip fracture and 200 without fractures, admitted after a fall between January 2005 and December 2007. Results: Serum total osteocalcin levels were significantly lower in the fracture group compared to the non-fracture group (20.4ng/ml vs 26.1ng/ml, respectively, p = 0.01). This finding remained significant after exclusion of the patients on bisphosphonates (p = 0.003). There were no significant differences in 25OHD, PTH or CTX levels between the two groups. Conclusion: In the current study there was an association between the presence of a hip fracture and lower total serum osteocalcin concentrations. This could be indicative of low bone turnover osteoporosis in these women. An association for other bone turnover markers was lacking. Springer-Verlag Berlin Heidelberg, 2014 Hip fracture nationallicence Falls nationallicence Elderly women nationallicence Osteoporosis nationallicence Total osteocalcin nationallicence Hüftnahe Frakturen nationallicence Stürze nationallicence Ältere Patientinnen nationallicence Osteoporose nationallicence Gesamtosteocalcin nationallicence Thaler Heinrich W. Trauma Hospital Meidling, Kundratstraße 37, 1120, Vienna, Austria aut Oudshoorn Christian Section of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands aut Hartholt Klaas A. Department of Surgery, Reinier de Graaf Group, Delft, The Netherlands aut van der Cammen Tischa J.M. Section of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands aut Zeitschrift für Gerontologie und Geriatrie Springer Berlin Heidelberg 48/6(2015-08-01), 539-542 0948-6704 48:6<539 2015 48 391 https://doi.org/10.1007/s00391-014-0843-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00391-014-0843-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Thaler Heinrich W. Trauma Hospital Meidling, Kundratstraße 37, 1120, Vienna, Austria aut NATIONALLICENCE 700 1- Oudshoorn Christian Section of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Hartholt Klaas A. Department of Surgery, Reinier de Graaf Group, Delft, The Netherlands aut NATIONALLICENCE 700 1- van der Cammen Tischa J.M. Section of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands aut NATIONALLICENCE 773 0- Zeitschrift für Gerontologie und Geriatrie Springer Berlin Heidelberg 48/6(2015-08-01), 539-542 0948-6704 48:6<539 2015 48 391