caa a22 4500 606191291 CHVBK 20210128100859.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00391-015-0938-4 doi (NATIONALLICENCE)springer-10.1007/s00391-015-0938-4 C-reactive protein and the acute phase reaction in geriatric patients [Elektronische Daten] [Thomas Bertsch, Jakob Triebel, Cornelius Bollheimer, Michael Christ, Cornel Sieber, Klaus Fassbender, Hans Jürgen Heppner] C-reaktives Protein und die Akute-Phase-Reaktion bei geriatrischen Patienten The C-reactive protein (CRP), first described as a serum component capable of precipitating the C-polysaccharide of pneumococci, is one of the most important proteins because the serum concentration rises in the acute phase reaction. The acute phase reaction is the nonspecific reaction of the body to noxious stimuli of the most varied kinds, such as infections, burns, neoplasms and tissue trauma. The CRP is synthesized in liver parenchymal cells by cytokines which are derived from stimulated leucocytes and released into the circulation. Because of its molecular structure and in synergy with the complement system, it is able to precipitate and/or lyse microorganisms, thereby rendering them harmless. Measurement of the serum CRP concentration can provide important information with respect to the diagnosis and monitoring of treatment. Due to immunosenescence in geriatric patients the synthesis of CRP appears to be limited to inflammatory stimuli; however, this phenomenon does not appear to be of major clinical relevance. Despite the introduction of new parameters of the acute phase reaction, sometimes with better performance, such as interleukin-6, procalcitonin and the soluble endotoxin receptor sCD14, measurement of CRP for diagnosis and treatment monitoring is still justified even in geriatric patients as testing is rapid, economic and nearly ubiquitously available round the clock. Biochemical markers of the acute phase reaction should always be interpreted together with the clinical picture and their specific limitations. Springer-Verlag Berlin Heidelberg, 2015 C-reactive protein nationallicence Acute phase reaction nationallicence Infection nationallicence Innate immune response nationallicence Geriatrics nationallicence C-reaktives Protein nationallicence Akute-Phase-Reaktion nationallicence Infektion nationallicence Angeborene Immunantwort nationallicence Geriatrie nationallicence Bertsch Thomas Institute of Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, Paracelsus Medical University, General Hospital Nuremberg, Prof. Ernst-Nathan-Str. 1, 90419, Nuremberg, Germany aut Triebel Jakob Institute of Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, Paracelsus Medical University, General Hospital Nuremberg, Prof. Ernst-Nathan-Str. 1, 90419, Nuremberg, Germany aut Bollheimer Cornelius Department of General Internal Medicine and Geriatrics, St. John of God Hospital Regensburg, Regensburg, Germany aut Christ Michael Department of Emergency Medicine and Intensive Care, Paracelsus Medical University, General Hospital Nuremberg, Nuremberg, Germany aut Sieber Cornel Department of General Internal Medicine and Geriatrics, St. John of God Hospital Regensburg, Regensburg, Germany aut Fassbender Klaus Department of Neurology, Saarland University Hospital, Homburg, Germany aut Heppner Hans Jürgen Department of Geriatrics, Helios Klinikum Schwelm -Chair of Geriatrics of Witten-Herdecke University, Schwelm, Germany aut Zeitschrift für Gerontologie und Geriatrie Springer Berlin Heidelberg 48/7(2015-10-01), 595-600 0948-6704 48:7<595 2015 48 391 https://doi.org/10.1007/s00391-015-0938-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00391-015-0938-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bertsch Thomas Institute of Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, Paracelsus Medical University, General Hospital Nuremberg, Prof. Ernst-Nathan-Str. 1, 90419, Nuremberg, Germany aut NATIONALLICENCE 700 1- Triebel Jakob Institute of Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, Paracelsus Medical University, General Hospital Nuremberg, Prof. Ernst-Nathan-Str. 1, 90419, Nuremberg, Germany aut NATIONALLICENCE 700 1- Bollheimer Cornelius Department of General Internal Medicine and Geriatrics, St. John of God Hospital Regensburg, Regensburg, Germany aut NATIONALLICENCE 700 1- Christ Michael Department of Emergency Medicine and Intensive Care, Paracelsus Medical University, General Hospital Nuremberg, Nuremberg, Germany aut NATIONALLICENCE 700 1- Sieber Cornel Department of General Internal Medicine and Geriatrics, St. John of God Hospital Regensburg, Regensburg, Germany aut NATIONALLICENCE 700 1- Fassbender Klaus Department of Neurology, Saarland University Hospital, Homburg, Germany aut NATIONALLICENCE 700 1- Heppner Hans Jürgen Department of Geriatrics, Helios Klinikum Schwelm -Chair of Geriatrics of Witten-Herdecke University, Schwelm, Germany aut NATIONALLICENCE 773 0- Zeitschrift für Gerontologie und Geriatrie Springer Berlin Heidelberg 48/7(2015-10-01), 595-600 0948-6704 48:7<595 2015 48 391