caa a22 4500 606192069 CHVBK 20210128100903.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00391-014-0840-5 doi (NATIONALLICENCE)springer-10.1007/s00391-014-0840-5 Predicting fatigue in older breast cancer patients receiving radiotherapy [Elektronische Daten] A head-to-head comparison of established assessments [Michael Dieter Denkinger, Melanie Hasch, Anna Gerstmayer, Rolf Kreienberg, Thorsten Nikolaus, Katharina Hancke] Kann man die Entwicklung einer Fatigue bei älteren Patientinnen mit Mammakarzinom und Radiotherapie vorhersagen? Ein direkter Vergleich etablierter Bewertungsverfahren Objectives: Because of substantial toxicities in older adults, chemotherapy is often omitted while the frequency of radiotherapy changes only minimally. In this study, we addressed the value of different assessments for predicting fatigue after radiotherapy in older breast cancer patients. Patients and methods: We included 74 women with primary breast cancer over the age of 65years treated with radiotherapy (26 % with additional chemotherapy). Assessments were conducted before adjuvant treatment and after radiotherapy. The assessments included the Vulnerable Elders Survey (VES-13), the Karnofsky Performance Status (KPS), the EORTC Quality of Life assessment (EORTC-QLQ-C30), a cancer-specific comprehensive geriatric assessment (cancer-specific CGA), and the Fried frailty score. Multiple linear regression analyses were used to assess correlations with the FACIT-fatigue scale. Results: Patients were on average 71years old (range, 65-86years). Most tumors (n=62)were classified as intermediate risk according to the St. Gallen consensus. The cancer-specific CGA was best associated with fatigue (p < 0.001, β estimate = 1.75), followed by the Fried frailty score (for the score of 1 versus reference of 2 and higher: p = 0.035, β estimate = − 5.74). There were no significant ceiling effects but there were substantial floor effects for the VES-13, KPS, and frailty score. Conclusion: The cancer-specific CGA and the Fried frailty score (driven mainly by the item "exhaustion”) outperformed the other indices in predicting fatigue in a group of rather well-functioning older women with primary breast cancer. Springer-Verlag Berlin Heidelberg, 2014 Geriatric oncology nationallicence Geriatric assessment nationallicence Breast cancer nationallicence Fatigue nationallicence Radiotherapy nationallicence Geriatrische Onkologie nationallicence Geriatrisches Assessment nationallicence Brustkrebs nationallicence Radiotherapie nationallicence Denkinger Michael Dieter AGAPLESION Bethesda Klinik Ulm, Geriatrie der Universität Ulm, Zollernring 26, 89073, Ulm, Deutschland aut Hasch Melanie Universitätsfrauenklinik Ulm, Prittwitzstr. 43, 89075, Ulm, Deutschland aut Gerstmayer Anna Universitätsfrauenklinik Ulm, Prittwitzstr. 43, 89075, Ulm, Deutschland aut Kreienberg Rolf Universitätsfrauenklinik Ulm, Prittwitzstr. 43, 89075, Ulm, Deutschland aut Nikolaus Thorsten AGAPLESION Bethesda Klinik Ulm, Geriatrie der Universität Ulm, Zollernring 26, 89073, Ulm, Deutschland aut Hancke Katharina Universitätsfrauenklinik Ulm, Prittwitzstr. 43, 89075, Ulm, Deutschland aut Zeitschrift für Gerontologie und Geriatrie Springer Berlin Heidelberg 48/2(2015-02-01), 128-134 0948-6704 48:2<128 2015 48 391 https://doi.org/10.1007/s00391-014-0840-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00391-014-0840-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Denkinger Michael Dieter AGAPLESION Bethesda Klinik Ulm, Geriatrie der Universität Ulm, Zollernring 26, 89073, Ulm, Deutschland aut NATIONALLICENCE 700 1- Hasch Melanie Universitätsfrauenklinik Ulm, Prittwitzstr. 43, 89075, Ulm, Deutschland aut NATIONALLICENCE 700 1- Gerstmayer Anna Universitätsfrauenklinik Ulm, Prittwitzstr. 43, 89075, Ulm, Deutschland aut NATIONALLICENCE 700 1- Kreienberg Rolf Universitätsfrauenklinik Ulm, Prittwitzstr. 43, 89075, Ulm, Deutschland aut NATIONALLICENCE 700 1- Nikolaus Thorsten AGAPLESION Bethesda Klinik Ulm, Geriatrie der Universität Ulm, Zollernring 26, 89073, Ulm, Deutschland aut NATIONALLICENCE 700 1- Hancke Katharina Universitätsfrauenklinik Ulm, Prittwitzstr. 43, 89075, Ulm, Deutschland aut NATIONALLICENCE 773 0- Zeitschrift für Gerontologie und Geriatrie Springer Berlin Heidelberg 48/2(2015-02-01), 128-134 0948-6704 48:2<128 2015 48 391