caa a22 4500 606194630 CHVBK 20210128100915.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s10934-014-9897-1 doi (NATIONALLICENCE)springer-10.1007/s10934-014-9897-1 Novel wrinkled periodic mesoporous organosilica nanoparticles for hydrophobic anticancer drug delivery [Elektronische Daten] [Imalka Munaweera, Jessica Hong, Alicia D'Souza, Kenneth Balkus Jr.] Novel wrinkled structured periodic mesoporous organosilica (PMO) nanoparticles have been developed for the hydrophobic anticancer drug delivery. The PMO materials were characterized by TEM, Raman, TGA, zetapotential and PXRD. These novel wrinkled PMOs have tunable surface area, hydrophobicity and pore sizes which are suitable for hydrophobic drug delivery. The hydrophobic anticancer drug paclitaxel was used as a model drug and the PMO shows a higher paclitaxel drug loading efficiency compared to pure mesoporous silica (MS) nanoaparticles. In vitro paclitaxel drug release studies show slow and sustained release of paclitaxel drugs from the PMO nanoparticles compared to the paclitaxel release from MS nanoparticles. Springer Science+Business Media New York, 2014 Wrinkled structure nationallicence Periodic mesoporous organosilica nationallicence Nanoparticles nationallicence Drug delivery nationallicence Hydrophobic drug nationallicence Munaweera Imalka Department of Chemistry, University of Texas at Dallas, 800 West Campbell Rd., 75080, Richardson, TX, USA aut Hong Jessica Department of Chemistry, University of Texas at Dallas, 800 West Campbell Rd., 75080, Richardson, TX, USA aut D'Souza Alicia Department of Chemistry, University of Texas at Dallas, 800 West Campbell Rd., 75080, Richardson, TX, USA aut Balkus Jr. Kenneth Department of Chemistry, University of Texas at Dallas, 800 West Campbell Rd., 75080, Richardson, TX, USA aut Journal of Porous Materials Springer US; http://www.springer-ny.com 22/1(2015-02-01), 1-10 1380-2224 22:1<1 2015 22 10934 https://doi.org/10.1007/s10934-014-9897-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10934-014-9897-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Munaweera Imalka Department of Chemistry, University of Texas at Dallas, 800 West Campbell Rd., 75080, Richardson, TX, USA aut NATIONALLICENCE 700 1- Hong Jessica Department of Chemistry, University of Texas at Dallas, 800 West Campbell Rd., 75080, Richardson, TX, USA aut NATIONALLICENCE 700 1- D'Souza Alicia Department of Chemistry, University of Texas at Dallas, 800 West Campbell Rd., 75080, Richardson, TX, USA aut NATIONALLICENCE 700 1- Balkus Jr Kenneth Department of Chemistry, University of Texas at Dallas, 800 West Campbell Rd., 75080, Richardson, TX, USA aut NATIONALLICENCE 773 0- Journal of Porous Materials Springer US; http://www.springer-ny.com 22/1(2015-02-01), 1-10 1380-2224 22:1<1 2015 22 10934