caa a22 4500 606194851 CHVBK 20210128100916.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10934-015-0027-5 doi (NATIONALLICENCE)springer-10.1007/s10934-015-0027-5 In vitro bioactivity and drug release kinetics studies of mesoporous silica-biopolymer composites [Elektronische Daten] [M. Narasimha Reddy, K. Cheralathan, S. Sasikumar] Targeted drug delivery systems become highly significant in certain diseases where the required dosage of drug cannot be delivered due to poor blood circulation in the targeted hard tissues. The present study reports a simple method of preparing mesoporous silica (SBA-15)/Biopolymer composite and loading an antibiotic in the silica scaffold which may find applications in bone drug delivery system. The SBA-15 was prepared under different conditions and analyzed for its texture and structural properties. The as prepared silica was characterized by low angle X-ray diffraction and BET surface area measurement which shows mesoporosity associated with hexagonally organized channels, a narrow pore size distribution and a large surface area. Chitin and Chitosan were the biopolymers used in the preparation of composites and bioactivity of the composites was investigated in the SBF medium. Ciprofloxacin was used as a model drug molecule in the drug delivery studies as its molecular size is suitable for inclusion within the mesopores of the SBA-15 material. The in vitro drug release was investigated in the simulated body fluid medium. The mesoporous silica's were found to be highly bioactive and found to possess sustained drug delivery kinetics. Springer Science+Business Media New York, 2015 Mesoporous silica nationallicence Drug delivery system nationallicence Antibiotics nationallicence Powder X-ray diffraction nationallicence Narasimha Reddy M. Materials Chemistry Division, School of Advanced Sciences, VIT University, 632014, Vellore, Tamil Nadu, India aut Cheralathan K. Materials Chemistry Division, School of Advanced Sciences, VIT University, 632014, Vellore, Tamil Nadu, India aut Sasikumar S. Materials Chemistry Division, School of Advanced Sciences, VIT University, 632014, Vellore, Tamil Nadu, India aut Journal of Porous Materials Springer US; http://www.springer-ny.com 22/6(2015-12-01), 1465-1472 1380-2224 22:6<1465 2015 22 10934 https://doi.org/10.1007/s10934-015-0027-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10934-015-0027-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Narasimha Reddy M. Materials Chemistry Division, School of Advanced Sciences, VIT University, 632014, Vellore, Tamil Nadu, India aut NATIONALLICENCE 700 1- Cheralathan K. Materials Chemistry Division, School of Advanced Sciences, VIT University, 632014, Vellore, Tamil Nadu, India aut NATIONALLICENCE 700 1- Sasikumar S. Materials Chemistry Division, School of Advanced Sciences, VIT University, 632014, Vellore, Tamil Nadu, India aut NATIONALLICENCE 773 0- Journal of Porous Materials Springer US; http://www.springer-ny.com 22/6(2015-12-01), 1465-1472 1380-2224 22:6<1465 2015 22 10934