caa a22 4500 606195246 CHVBK 20210128100918.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10934-015-9955-3 doi (NATIONALLICENCE)springer-10.1007/s10934-015-9955-3 Mesoporous drug carrier systems for enhanced delivery rate of poorly water-soluble drug: nimodipine [Elektronische Daten] [Anna Kiwilsza, Bartłomiej Milanowski, Kacper Drużbicki, L. Coy, Mikołaj Grzeszkowiak, Marcin Jarek, Jadwiga Mielcarek, Janina Lulek, Aleksandra Pajzderska, Jan Wąsicki] Two mesoporous silica materials: MCM-41 and SBA-15 were applied as potential nanocarriers for poorly soluble drug—nimodipine. Drug incorporation was performed using modified adsorption from the solution method and loaded samples before and after washing procedure were studied. The physical properties were verified by: differential scanning calorimetry, X-ray powder diffraction, electron microscopies (SEM/TEM) and Fourier-transform infrared spectroscopy (FT-IR). FT-IR results for bulk nimodipine were interpreted on the basis of first principles calculations (DFT). As a result of encapsulation process, in both matrices nimodipine appeared simultaneously in two forms: crystalline and amorphous, but the first one turned out to be easily removable during washing procedure. The in vitro dissolution and release tests were performed with ultra pure water under supersaturating conditions. The release rate of the amorphous nimodipine from mesoporous silica materials was at least 70 times higher than dissolution rate of bulk drug, thus revealed a potential usefulness of such carrier in future pharmaceutical applications in terms of delivery of poorly soluble drugs. The Author(s), 2015 Nimodipine nationallicence Mesoporous silica nationallicence MCM-41 nationallicence SBA-15 nationallicence Dissolution nationallicence Release rate nationallicence Kiwilsza Anna Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61-614, Poznan, Poland aut Milanowski Bartłomiej Department of Pharmaceutical Technology, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznan, Poland aut Drużbicki Kacper Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61-614, Poznan, Poland aut Coy L. NanoBioMedical Center, Adam Mickiewicz University, Umultowska 85, 61-614, Poznan, Poland aut Grzeszkowiak Mikołaj Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61-614, Poznan, Poland aut Jarek Marcin NanoBioMedical Center, Adam Mickiewicz University, Umultowska 85, 61-614, Poznan, Poland aut Mielcarek Jadwiga Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznan, Poland aut Lulek Janina Department of Pharmaceutical Technology, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznan, Poland aut Pajzderska Aleksandra Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61-614, Poznan, Poland aut Wąsicki Jan Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61-614, Poznan, Poland aut Journal of Porous Materials Springer US; http://www.springer-ny.com 22/3(2015-06-01), 817-829 1380-2224 22:3<817 2015 22 10934 https://doi.org/10.1007/s10934-015-9955-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10934-015-9955-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kiwilsza Anna Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61-614, Poznan, Poland aut NATIONALLICENCE 700 1- Milanowski Bartłomiej Department of Pharmaceutical Technology, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznan, Poland aut NATIONALLICENCE 700 1- Drużbicki Kacper Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61-614, Poznan, Poland aut NATIONALLICENCE 700 1- Coy L. NanoBioMedical Center, Adam Mickiewicz University, Umultowska 85, 61-614, Poznan, Poland aut NATIONALLICENCE 700 1- Grzeszkowiak Mikołaj Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61-614, Poznan, Poland aut NATIONALLICENCE 700 1- Jarek Marcin NanoBioMedical Center, Adam Mickiewicz University, Umultowska 85, 61-614, Poznan, Poland aut NATIONALLICENCE 700 1- Mielcarek Jadwiga Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznan, Poland aut NATIONALLICENCE 700 1- Lulek Janina Department of Pharmaceutical Technology, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznan, Poland aut NATIONALLICENCE 700 1- Pajzderska Aleksandra Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61-614, Poznan, Poland aut NATIONALLICENCE 700 1- Wąsicki Jan Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61-614, Poznan, Poland aut NATIONALLICENCE 773 0- Journal of Porous Materials Springer US; http://www.springer-ny.com 22/3(2015-06-01), 817-829 1380-2224 22:3<817 2015 22 10934