caa a22 4500 606195645 CHVBK 20210128100920.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10934-015-9966-0 doi (NATIONALLICENCE)springer-10.1007/s10934-015-9966-0 Modification of inorganic porous materials as gene vectors: an overview [Elektronische Daten] [Feng Liu, Li Zhao, Ning An, Dong Tong, Wei Yu, Chun Zhou] The use of porous materials as gene vectors is becoming more important and striking than their traditional uses in catalysis and separation. This article highlights recent advances in the modification of typical inorganic porous materials which are specifically and necessarily conducted for their uses as gene vectors. Literature survey indicates that carbon nanotubes, layered double hydroxides, mesoporous silica and carbon nanoparticles and the related hierarchical materials have received particular attention in recent years. Though these inorganic porous materials have high surface area and porosity, to choose surface modification judiciously is often required for improving their performances in the loading of genes, targeted delivery and controlled release of genes. Major modification methods are adsorption or grafting of other molecules onto the surface of these inorganic porous materials. In addition, modification by adding magnetic nanoparticles to the porous materials has been investigated. Nevertheless, thus far most studies on the modification have aimed merely at the improvement of the loading, the delivery and the release of gene. Exact biocompatibility and in vivo therapy effectiveness remains elusive and are still in question. Springer Science+Business Media New York, 2015 Gene vector nationallicence Porous materials nationallicence Nanotube nationallicence Layered double hydroxides nationallicence Mesoporous silica nationallicence Cancer therapy nationallicence Liu Feng Research Group for Advanced Materials and Sustainable Catalysis (AMSC), College of Chemical Engineering, Zhejiang University of Technology, 310014, Hangzhou, People's Republic of China aut Zhao Li Research Group for Advanced Materials and Sustainable Catalysis (AMSC), College of Chemical Engineering, Zhejiang University of Technology, 310014, Hangzhou, People's Republic of China aut An Ning Research Group for Advanced Materials and Sustainable Catalysis (AMSC), College of Chemical Engineering, Zhejiang University of Technology, 310014, Hangzhou, People's Republic of China aut Tong Dong Research Group for Advanced Materials and Sustainable Catalysis (AMSC), College of Chemical Engineering, Zhejiang University of Technology, 310014, Hangzhou, People's Republic of China aut Yu Wei Research Group for Advanced Materials and Sustainable Catalysis (AMSC), College of Chemical Engineering, Zhejiang University of Technology, 310014, Hangzhou, People's Republic of China aut Zhou Chun Research Group for Advanced Materials and Sustainable Catalysis (AMSC), College of Chemical Engineering, Zhejiang University of Technology, 310014, Hangzhou, People's Republic of China aut Journal of Porous Materials Springer US; http://www.springer-ny.com 22/4(2015-08-01), 927-937 1380-2224 22:4<927 2015 22 10934 https://doi.org/10.1007/s10934-015-9966-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10934-015-9966-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu Feng Research Group for Advanced Materials and Sustainable Catalysis (AMSC), College of Chemical Engineering, Zhejiang University of Technology, 310014, Hangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Zhao Li Research Group for Advanced Materials and Sustainable Catalysis (AMSC), College of Chemical Engineering, Zhejiang University of Technology, 310014, Hangzhou, People's Republic of China aut NATIONALLICENCE 700 1- An Ning Research Group for Advanced Materials and Sustainable Catalysis (AMSC), College of Chemical Engineering, Zhejiang University of Technology, 310014, Hangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Tong Dong Research Group for Advanced Materials and Sustainable Catalysis (AMSC), College of Chemical Engineering, Zhejiang University of Technology, 310014, Hangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Yu Wei Research Group for Advanced Materials and Sustainable Catalysis (AMSC), College of Chemical Engineering, Zhejiang University of Technology, 310014, Hangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Zhou Chun Research Group for Advanced Materials and Sustainable Catalysis (AMSC), College of Chemical Engineering, Zhejiang University of Technology, 310014, Hangzhou, People's Republic of China aut NATIONALLICENCE 773 0- Journal of Porous Materials Springer US; http://www.springer-ny.com 22/4(2015-08-01), 927-937 1380-2224 22:4<927 2015 22 10934