caa a22 4500 606196188 CHVBK 20210128100923.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10934-015-9913-0 doi (NATIONALLICENCE)springer-10.1007/s10934-015-9913-0 Controlled release of Diclofenac, an anti-inflammatory drug by nanocompositing with layered zinc hydroxide [Elektronische Daten] [Hafezeh Nabipour, Moayad Sadr] The anti-inflammatory drug, Diclofenac (DIC) anion, was intercalated into the layered zinc hydroxide (LZH) by ion-exchange method. Then, the DIC-LZH/Chitosan nanocomposite was prepared by coating of Chitosan on DIC-LZH. LZH intercalated with DIC was successfully encapsulated into Chitosan by precipitation method. The structures of the obtained products were studied by powder X-ray diffraction, FT-IR spectroscopy, scanning electron microscopy, and thermal analysis. The XRD patterns and FTIR analyses showed that the DIC was successfully intercalated into the LZH interlayer space with an average basal spacing of 29.42Å. Thermal analysis studies confirmed that the thermal stability of DIC was enhanced after intercalation into LZH. In addition, drug release behaviors in vitro of DIC from DIC-LZH and DIC-LZH/Chitosan nanocomposites were observed in phosphate buffer solution under the conditions of pH 4.8 and 7.4, respectively. Springer Science+Business Media New York, 2015 Diclofenac nationallicence Layered zinc hydroxide nationallicence Drug release nationallicence Nanocomposite nationallicence Nabipour Hafezeh Chemistry Department, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran aut Sadr Moayad Chemistry Department, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran aut Journal of Porous Materials Springer US; http://www.springer-ny.com 22/2(2015-04-01), 447-454 1380-2224 22:2<447 2015 22 10934 https://doi.org/10.1007/s10934-015-9913-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10934-015-9913-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nabipour Hafezeh Chemistry Department, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran aut NATIONALLICENCE 700 1- Sadr Moayad Chemistry Department, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran aut NATIONALLICENCE 773 0- Journal of Porous Materials Springer US; http://www.springer-ny.com 22/2(2015-04-01), 447-454 1380-2224 22:2<447 2015 22 10934