caa a22 4500 606197354 CHVBK 20210128100929.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00348-015-1966-y doi (NATIONALLICENCE)springer-10.1007/s00348-015-1966-y Three-dimensional inspiratory flow in the upper and central human airways [Elektronische Daten] [A. Banko, F. Coletti, D. Schiavazzi, C. Elkins, J. Eaton] The steady inspiratory flow through an anatomically accurate model of the human airways was studied experimentally at a regime relevant to deep inspiration for aerosol drug delivery. Magnetic resonance velocimetry was used to obtain the three-component, mean velocity field. A strong, single-sided streamwise swirl was found in the trachea and persists up to the first bifurcation. There, the swirl and the asymmetric anatomy impact both the streamwise momentum distribution and the secondary flows in the main bronchi, with large differences compared to what is found in idealized branching tubes. In further generations, the streamwise velocity never recovers a symmetric profile and the relative intensity of the secondary flows remains strong. Overall, the results suggest that, in real human airways, both streamwise dispersion (due to streamwise gradients) and lateral dispersion (due to secondary flows) are very effective transport mechanisms. Neglecting the extrathoracic airways and idealizing the bronchial tree may lead to qualitatively different conclusions. Springer-Verlag Berlin Heidelberg, 2015 Banko A. Department of Mechanical Engineering, Stanford University, 94305, Stanford, CA, USA aut Coletti F. Department of Aerospace Engineering and Mechanics, University of Minnesota, 55455, Minneapolis, MN, USA aut Schiavazzi D. Department of Mechanical and Aerospace Engineering, University of California at San Diego, 92093, La Jolla, CA, USA aut Elkins C. Department of Mechanical Engineering, Stanford University, 94305, Stanford, CA, USA aut Eaton J. Department of Mechanical Engineering, Stanford University, 94305, Stanford, CA, USA aut Experiments in Fluids Springer Berlin Heidelberg 56/6(2015-06-01), 1-12 0723-4864 56:6<1 2015 56 348 https://doi.org/10.1007/s00348-015-1966-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00348-015-1966-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Banko A. Department of Mechanical Engineering, Stanford University, 94305, Stanford, CA, USA aut NATIONALLICENCE 700 1- Coletti F. Department of Aerospace Engineering and Mechanics, University of Minnesota, 55455, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Schiavazzi D. Department of Mechanical and Aerospace Engineering, University of California at San Diego, 92093, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Elkins C. Department of Mechanical Engineering, Stanford University, 94305, Stanford, CA, USA aut NATIONALLICENCE 700 1- Eaton J. Department of Mechanical Engineering, Stanford University, 94305, Stanford, CA, USA aut NATIONALLICENCE 773 0- Experiments in Fluids Springer Berlin Heidelberg 56/6(2015-06-01), 1-12 0723-4864 56:6<1 2015 56 348