caa a22 4500 606199977 CHVBK 20210128100941.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10653-014-9666-8 doi (NATIONALLICENCE)springer-10.1007/s10653-014-9666-8 Toxic metals signature in the human seminal plasma of Pakistani population and their potential role in male infertility [Elektronische Daten] [Ambreen Zafar, Syed Eqani, Nazish Bostan, Alessandra Cincinelli, Faheem Tahir, Syed Shah, Alamdar Hussain, Ambreen Alamdar, Qingyu Huang, Siyuan Peng, Heqing Shen] Aims of this study were to provide firsthand data on the incidence of trace metals in human seminal plasma and find possible correlations between levels of toxic metals and semen quality of Pakistani population. Human semen samples were collected from male partners of couples undergoing infertility assessment at the National Institute of Health Islamabad (Pakistan). We investigated seventy-five seminal plasma samples, which were further categorized into three groups (normozoospermia, oligozoospermia and azoospermia) according to WHO guidelines. The concentration of 17 different toxic metals in human seminal plasma was determined simultaneously by using Inductively coupled plasma mass spectrometry (ICP-MS). Out of 17 trace metals, Cd and Ni showed significant difference (p<0.05) among three monitored groups. Ni and Cd concentrations in the seminal plasma were negatively correlated with sperm concentration (r=−0.26, −0.29) and motility (r=−0.33, −0.37), respectively. This study suggested that exposure of Ni and Cd is mainly related with the consumption of contaminated dietary items, including ghee (cooking oil), flour and other agri-products. In some semen samples, the concentrations of Sn, V, Cu, Pb, Cr and Hg exhibited high levels suggesting a recent human exposure to surrounding sources. In Pakistani human semen samples, the levels of trace metals were lower and/or comparable to that found in populations of other countries. The results show the first evidence of the effect of toxic metals on semen quality and male infertility in Pakistan. Springer Science+Business Media Dordrecht, 2014 Human semen nationallicence Toxic metals nationallicence ICP-MS nationallicence Male infertility nationallicence Pakistan nationallicence Zafar Ambreen Public Health and Environment Division, Department of Biosciences, COMSAT Institute of Information and Technology, Islamabad, Pakistan aut Eqani Syed Public Health and Environment Division, Department of Biosciences, COMSAT Institute of Information and Technology, Islamabad, Pakistan aut Bostan Nazish Public Health and Environment Division, Department of Biosciences, COMSAT Institute of Information and Technology, Islamabad, Pakistan aut Cincinelli Alessandra Department of Chemistry, University of Florence, Via della Lastruccia 3, Sesto Fiorentino, 50019, Florence, Italy aut Tahir Faheem Reproductive Health Department, Public Health Laboratories Division, National Institute of Health, Islamabad, Pakistan aut Shah Syed Public Health and Environment Division, Department of Biosciences, COMSAT Institute of Information and Technology, Islamabad, Pakistan aut Hussain Alamdar Public Health and Environment Division, Department of Biosciences, COMSAT Institute of Information and Technology, Islamabad, Pakistan aut Alamdar Ambreen Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, 361021, Xiamen, People's Republic of China aut Huang Qingyu Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, 361021, Xiamen, People's Republic of China aut Peng Siyuan Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, 361021, Xiamen, People's Republic of China aut Shen Heqing Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, 361021, Xiamen, People's Republic of China aut Environmental Geochemistry and Health Springer Netherlands 37/3(2015-06-01), 515-527 0269-4042 37:3<515 2015 37 10653 https://doi.org/10.1007/s10653-014-9666-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10653-014-9666-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zafar Ambreen Public Health and Environment Division, Department of Biosciences, COMSAT Institute of Information and Technology, Islamabad, Pakistan aut NATIONALLICENCE 700 1- Eqani Syed Public Health and Environment Division, Department of Biosciences, COMSAT Institute of Information and Technology, Islamabad, Pakistan aut NATIONALLICENCE 700 1- Bostan Nazish Public Health and Environment Division, Department of Biosciences, COMSAT Institute of Information and Technology, Islamabad, Pakistan aut NATIONALLICENCE 700 1- Cincinelli Alessandra Department of Chemistry, University of Florence, Via della Lastruccia 3, Sesto Fiorentino, 50019, Florence, Italy aut NATIONALLICENCE 700 1- Tahir Faheem Reproductive Health Department, Public Health Laboratories Division, National Institute of Health, Islamabad, Pakistan aut NATIONALLICENCE 700 1- Shah Syed Public Health and Environment Division, Department of Biosciences, COMSAT Institute of Information and Technology, Islamabad, Pakistan aut NATIONALLICENCE 700 1- Hussain Alamdar Public Health and Environment Division, Department of Biosciences, COMSAT Institute of Information and Technology, Islamabad, Pakistan aut NATIONALLICENCE 700 1- Alamdar Ambreen Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, 361021, Xiamen, People's Republic of China aut NATIONALLICENCE 700 1- Huang Qingyu Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, 361021, Xiamen, People's Republic of China aut NATIONALLICENCE 700 1- Peng Siyuan Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, 361021, Xiamen, People's Republic of China aut NATIONALLICENCE 700 1- Shen Heqing Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, 361021, Xiamen, People's Republic of China aut NATIONALLICENCE 773 0- Environmental Geochemistry and Health Springer Netherlands 37/3(2015-06-01), 515-527 0269-4042 37:3<515 2015 37 10653