caa a22 4500 606200029 CHVBK 20210128100941.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10653-014-9675-7 doi (NATIONALLICENCE)springer-10.1007/s10653-014-9675-7 Multi-pathway assessment of human health risk posed by polycyclic aromatic hydrocarbons [Elektronische Daten] [Changsheng Qu, Bing Li, Haisuo Wu, Shui Wang, John Giesy] To assess aggregate exposure to polycyclic aromatic hydrocarbons (PAHs) via several environmental media and pathways, a probabilistic framework for multi-pathway health risk assessment that integrates PAHs potency equivalence factors, risk estimation modeling, and Monte Carlo simulation was applied to a case study in Nanjing, which is an important industrial city in China. Incremental lifetime risk of additional cancers posed by exposure to 16 USEPA priority PAHs in air, water, soil, and fish was assessed. Risks to three age groups, infants, children, and adults, through various exposure pathways, including oral ingestion, dermal absorption, and inhalation, were estimated. Results of the analysis of risk indicated that B[a]P, B[b]F, and BA were the predominant PAHs pollutants in Nanjing. Risk of additional cancer for local adults was on average 2.62×10−5. The risks were primarily due to ingestion of fish and inhalation, which contributed 99% of the total risks. By contrast, risk to infants was essentially negligible. Results of a sensitivity analysis indicated that the input variables of concentration of PAHs in fish (C f), the body weight (BW), and the ingestion rate of fish (IRf) were the major influences on estimates of risks. Springer Science+Business Media Dordrecht, 2015 PAHs nationallicence Environmental exposure nationallicence Multi-pathway nationallicence Monte Carlo simulation nationallicence Asia nationallicence Cancer nationallicence Qu Changsheng Key Laboratory of Environmental Engineering, Jiangsu Academy of Environmental Science, 210036, Nanjing, China aut Li Bing Key Laboratory of Environmental Engineering, Jiangsu Academy of Environmental Science, 210036, Nanjing, China aut Wu Haisuo Key Laboratory of Environmental Engineering, Jiangsu Academy of Environmental Science, 210036, Nanjing, China aut Wang Shui Key Laboratory of Environmental Engineering, Jiangsu Academy of Environmental Science, 210036, Nanjing, China aut Giesy John State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, 210023, Nanjing, China aut Environmental Geochemistry and Health Springer Netherlands 37/3(2015-06-01), 587-601 0269-4042 37:3<587 2015 37 10653 https://doi.org/10.1007/s10653-014-9675-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10653-014-9675-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Qu Changsheng Key Laboratory of Environmental Engineering, Jiangsu Academy of Environmental Science, 210036, Nanjing, China aut NATIONALLICENCE 700 1- Li Bing Key Laboratory of Environmental Engineering, Jiangsu Academy of Environmental Science, 210036, Nanjing, China aut NATIONALLICENCE 700 1- Wu Haisuo Key Laboratory of Environmental Engineering, Jiangsu Academy of Environmental Science, 210036, Nanjing, China aut NATIONALLICENCE 700 1- Wang Shui Key Laboratory of Environmental Engineering, Jiangsu Academy of Environmental Science, 210036, Nanjing, China aut NATIONALLICENCE 700 1- Giesy John State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, 210023, Nanjing, China aut NATIONALLICENCE 773 0- Environmental Geochemistry and Health Springer Netherlands 37/3(2015-06-01), 587-601 0269-4042 37:3<587 2015 37 10653