caa a22 4500 606200142 CHVBK 20210128100942.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10653-015-9682-3 doi (NATIONALLICENCE)springer-10.1007/s10653-015-9682-3 A review of the iodine status of UK pregnant women and its implications for the offspring [Elektronische Daten] [Sarah Bath, Margaret Rayman] Iodine, as a component of the thyroid hormones, is crucial for brain development and is therefore especially important during pregnancy when the brain is developing most rapidly. While randomised controlled trials of pregnant women in regions of severe iodine deficiency have shown that prenatal iodine deficiency causes impaired cognition, less is known of the effects in regions of mild deficiency. This is relevant to the UK as the World Health Organisation now classifies the UK as mildly iodine deficient, based on a national study of 14-15 year old schoolgirls in 2011. We have previously published a study using samples and data from the UK-based Avon Longitudinal Study of Parents and Children (ALSPAC) that found an association between low iodine status in early pregnancy (urinary iodine-to-creatinine ratio <150μg/g) and lower verbal IQ and reading scores in the offspring. Though the women in ALSPAC were recruited in the early 1990s, the results of the study are still relevant as their iodine status was similar to that reported in recent studies of UK pregnant women. This review discusses the evidence that mild-to-moderate iodine deficiency during pregnancy has deleterious effects on child neurodevelopment and relates that evidence to the data on iodine status in the UK. It has highlighted a need for nationwide data on iodine status of pregnant women and that a randomised controlled trial of iodine supplementation in pregnant women in a region of mild-to-moderate iodine deficiency with child outcomes as the primary endpoint is required. Springer Science+Business Media Dordrecht, 2015 Iodine nationallicence Nutrition nationallicence Pregnancy nationallicence UK nationallicence Cognition nationallicence Bath Sarah Department of Nutritional Sciences, Faculty of Health and Medical Sciences, School of Biosciences and Medicine, University of Surrey, GU2 7XH, Guildford, UK aut Rayman Margaret Department of Nutritional Sciences, Faculty of Health and Medical Sciences, School of Biosciences and Medicine, University of Surrey, GU2 7XH, Guildford, UK aut Environmental Geochemistry and Health Springer Netherlands 37/4(2015-08-01), 619-629 0269-4042 37:4<619 2015 37 10653 https://doi.org/10.1007/s10653-015-9682-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10653-015-9682-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bath Sarah Department of Nutritional Sciences, Faculty of Health and Medical Sciences, School of Biosciences and Medicine, University of Surrey, GU2 7XH, Guildford, UK aut NATIONALLICENCE 700 1- Rayman Margaret Department of Nutritional Sciences, Faculty of Health and Medical Sciences, School of Biosciences and Medicine, University of Surrey, GU2 7XH, Guildford, UK aut NATIONALLICENCE 773 0- Environmental Geochemistry and Health Springer Netherlands 37/4(2015-08-01), 619-629 0269-4042 37:4<619 2015 37 10653