caa a22 4500 606200460 CHVBK 20210128100943.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10653-014-9641-4 doi (NATIONALLICENCE)springer-10.1007/s10653-014-9641-4 Chronic kidney disease of unknown aetiology and ground-water ionicity: study based on Sri Lanka [Elektronische Daten] [M. Dharma-wardana, Sarath Amarasiri, Nande Dharmawardene, C. Panabokke] High incidence of chronic kidney disease of unknown aetiology (CKDU) in Sri Lanka is shown to correlate with the presence of irrigation works and rivers that bring-in ‘nonpoint source' fertilizer runoff from intensely agricultural regions. We review previous attempts to link CKDU with As, Cd and other standard toxins. Those studies (e.g. the WHO-sponsored study), while providing a wealth of data, are inconclusive in regard to aetiology. Here, we present new proposals based on increased ionicity of drinking water due to fertilizer runoff into the river system, redox processes in the soil and features of ‘tank'-cascades and aquifers. The consequent chronic exposure to high ionicity in drinking water is proposed to debilitate the kidney via a Hofmeister-type (i.e. protein-denaturing) mechanism. Springer Science+Business Media Dordrecht, 2014 Kidney disease nationallicence Water quality nationallicence Electrolytes nationallicence Protein denaturing nationallicence Fertilizers nationallicence Soils nationallicence Aquifers nationallicence Sri Lanka nationallicence Dharma-wardana M. National Research Council, K1A 0R6, Ottawa, ON, Canada aut Amarasiri Sarath Soil Science Society of Sri Lanka, P. O. Box 10, Peradeniya, Sri Lanka aut Dharmawardene Nande Bibile Sugar Industries, 620 Kotte Rd, Rajagiriya, Sri Lanka aut Panabokke C. International Water Management Institute, PO Box 2075, Colombo, Sri Lanka aut Environmental Geochemistry and Health Springer Netherlands 37/2(2015-04-01), 221-231 0269-4042 37:2<221 2015 37 10653 https://doi.org/10.1007/s10653-014-9641-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10653-014-9641-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dharma-wardana M. National Research Council, K1A 0R6, Ottawa, ON, Canada aut NATIONALLICENCE 700 1- Amarasiri Sarath Soil Science Society of Sri Lanka, P. O. Box 10, Peradeniya, Sri Lanka aut NATIONALLICENCE 700 1- Dharmawardene Nande Bibile Sugar Industries, 620 Kotte Rd, Rajagiriya, Sri Lanka aut NATIONALLICENCE 700 1- Panabokke C. International Water Management Institute, PO Box 2075, Colombo, Sri Lanka aut NATIONALLICENCE 773 0- Environmental Geochemistry and Health Springer Netherlands 37/2(2015-04-01), 221-231 0269-4042 37:2<221 2015 37 10653