caa a22 4500 606201084 CHVBK 20210128100946.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00429-013-0666-8 doi (NATIONALLICENCE)springer-10.1007/s00429-013-0666-8 Investigating the ventral-lexical, dorsal-sublexical model of basic reading processes using diffusion tensor imaging [Elektronische Daten] [Jacqueline Cummine, Wenjun Dai, Ron Borowsky, Layla Gould, Claire Rollans, Carol Boliek] Recent results from diffusion tensor imaging (DTI) studies provide evidence of a ventral-lexical stream and a dorsal-sublexical stream associated with reading processing. We investigated the relationship between behavioural reading speed for stimuli thought to rely on either the ventral-lexical, dorsal-sublexical, or both streams and white matter via fractional anisotropy (FA) and mean diffusivity (MD) using DTI tractography. Participants (N=32) overtly named exception words (e.g., ‘one', ventral-lexical), regular words (e.g., ‘won', both streams), nonwords (‘wum', dorsal-sublexical) and pseudohomophones (‘wun', dorsal-sublexical) in a behavioural lab. Each participant then underwent a brain scan that included a 30-directional DTI sequence. Tractography was used to extract FA and MD values from four tracts of interest: inferior longitudinal fasciculus, uncinate fasciculus, arcuate fasciculus, and inferior fronto-occipital fasciculus. Median reaction times (RTs) for reading exception words and regular words both showed a significant correlation with the FA of the uncinate fasciculus thought to underlie the ventral processing stream, such that response time decreased as FA increased. In addition, RT for exception and regular words showed a relationship with MD of the uncinate fasciculus, such that response time increased as MD increased. Multiple regression analyses revealed that exception word RT accounted for unique variability in FA of the uncinate over and above regular words. There were no robust relationships found between pseudohomophones, or nonwords, and tracts thought to underlie the dorsal processing stream. These results support the notion that word recognition, in general, and exception word reading in particular, rely on ventral-lexical brain regions. Springer-Verlag Berlin Heidelberg, 2013 Diffusion tensor imaging nationallicence Dorsal-sublexical processes nationallicence Ventral-lexical processes nationallicence Reading nationallicence Tractography nationallicence Cummine Jacqueline Department of Speech Pathology and Audiology, Faculty of Rehabilitation Medicine, University of Alberta, 2-70 8205 114st, T6G 2G4, Edmonton, AB, Canada aut Dai Wenjun Department of Speech Pathology and Audiology, Faculty of Rehabilitation Medicine, University of Alberta, 2-70 8205 114st, T6G 2G4, Edmonton, AB, Canada aut Borowsky Ron Department of Psychology, University of Saskatchewan, Saskatoon, Canada aut Gould Layla Department of Psychology, University of Saskatchewan, Saskatoon, Canada aut Rollans Claire Department of Cognitive Science, McGill University, Montreal, Canada aut Boliek Carol Department of Speech Pathology and Audiology, Faculty of Rehabilitation Medicine, University of Alberta, 2-70 8205 114st, T6G 2G4, Edmonton, AB, Canada aut Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 445-455 1863-2653 220:1<445 2015 220 429 https://doi.org/10.1007/s00429-013-0666-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-013-0666-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cummine Jacqueline Department of Speech Pathology and Audiology, Faculty of Rehabilitation Medicine, University of Alberta, 2-70 8205 114st, T6G 2G4, Edmonton, AB, Canada aut NATIONALLICENCE 700 1- Dai Wenjun Department of Speech Pathology and Audiology, Faculty of Rehabilitation Medicine, University of Alberta, 2-70 8205 114st, T6G 2G4, Edmonton, AB, Canada aut NATIONALLICENCE 700 1- Borowsky Ron Department of Psychology, University of Saskatchewan, Saskatoon, Canada aut NATIONALLICENCE 700 1- Gould Layla Department of Psychology, University of Saskatchewan, Saskatoon, Canada aut NATIONALLICENCE 700 1- Rollans Claire Department of Cognitive Science, McGill University, Montreal, Canada aut NATIONALLICENCE 700 1- Boliek Carol Department of Speech Pathology and Audiology, Faculty of Rehabilitation Medicine, University of Alberta, 2-70 8205 114st, T6G 2G4, Edmonton, AB, Canada aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 445-455 1863-2653 220:1<445 2015 220 429