caa a22 4500 606201114 CHVBK 20210128100946.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00429-013-0648-x doi (NATIONALLICENCE)springer-10.1007/s00429-013-0648-x Onset-related differences in neural substrates of tinnitus-related distress: the anterior cingulate cortex in late-onset tinnitus, and the frontal cortex in early-onset tinnitus [Elektronische Daten] [Jae-Jin Song, Sven Vanneste, Winfried Schlee, Paul Van de Heyning, Dirk De Ridder] Recent findings regarding differences in tinnitus-related neural activity according to onset age have raised a question on possible onset age-related differences in neural substrates of distress. Hence we collected quantitative electroencephalography (qEEG) findings of 28 late-onset tinnitus (LOT) and 29 early-onset tinnitus (EOT) (mean onset age 52.3 and 29.0years, respectively) participants. According to the tinnitus questionnaire (TQ) score grade, LOTs were then subdivided into 13 high distress (HD; TQ grade 3 or 4) and 15 low distress (LD; TQ grade 1 or 2), while EOTs into 14 HD and 15 LD. Compared to the EOT group, the LOT group demonstrated increased qEEG source-localized activity and functional connectivity primarily in the anterior cingulate cortex (ACC) and parahippocampus. In subgroup comparisons, the ACC was activated more in HD-LOT participants than in LD-LOT participants for the beta 1, beta 2 and gamma frequency bands, while the left orbitofrontal cortex and left dorsolateral prefrontal cortex were activated more in HD-EOT than in LD-EOT for the delta/beta and gamma frequency bands, respectively. Even with the same amount of tinnitus-related distress level, responsible neural substrates are different according to the onset age. These differences may be important for exploring different target areas of treatment according to tinnitus onset age, as well as for conducting similar studies on other pathologies, such as depression or pain. Springer-Verlag Berlin Heidelberg, 2013 Tinnitus nationallicence Anxiety nationallicence Aging nationallicence Electroencephalography nationallicence Gyrus cinguli nationallicence Prefrontal cortex nationallicence Song Jae-Jin Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Yun-Kun Dong 28, Chong-No Gu, 110-744, Seoul, Korea aut Vanneste Sven Department of Translational Neuroscience, Faculty of Medicine, University of Antwerp, Antwerp, Belgium aut Schlee Winfried Institute for Psychology and Education, University of Ulm, Ulm, Germany aut Van de Heyning Paul Department of Translational Neuroscience, Faculty of Medicine, University of Antwerp, Antwerp, Belgium aut De Ridder Dirk Section of Neurosurgery, Department of Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand aut Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 571-584 1863-2653 220:1<571 2015 220 429 https://doi.org/10.1007/s00429-013-0648-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-013-0648-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Song Jae-Jin Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Yun-Kun Dong 28, Chong-No Gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Vanneste Sven Department of Translational Neuroscience, Faculty of Medicine, University of Antwerp, Antwerp, Belgium aut NATIONALLICENCE 700 1- Schlee Winfried Institute for Psychology and Education, University of Ulm, Ulm, Germany aut NATIONALLICENCE 700 1- Van de Heyning Paul Department of Translational Neuroscience, Faculty of Medicine, University of Antwerp, Antwerp, Belgium aut NATIONALLICENCE 700 1- De Ridder Dirk Section of Neurosurgery, Department of Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 571-584 1863-2653 220:1<571 2015 220 429