caa a22 4500 606201122 CHVBK 20210128100946.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00429-013-0663-y doi (NATIONALLICENCE)springer-10.1007/s00429-013-0663-y Not on speaking terms: hallucinations and structural network disconnectivity in schizophrenia [Elektronische Daten] [Branislava Ćurčić-Blake, Luca Nanetti, Lisette van der Meer, Leonardo Cerliani, Remco Renken, Gerdina Pijnenborg, André Aleman] Auditory verbal hallucinations (AVH) in schizophrenia have previously been associated with functional deficiencies in language networks, specifically with functional disconnectivity in fronto-temporal connections in the left hemisphere and in interhemispheric connections between frontal regions. Here, we investigate whether AVH are accompanied by white matter abnormalities in tracts connecting the frontal, parietal and temporal lobes, also engaged during language tasks. We combined diffusion tensor imaging with tract-based spatial statistics and found white matter abnormalities in patients with schizophrenia as compared with healthy controls. The patients showed reduced fractional anisotropy bilaterally: in the anterior thalamic radiation (ATR), body of the corpus callosum (forceps minor), cingulum, temporal part of the superior longitudinal fasciculus (SLF) and a small area in the inferior fronto-occipital fasciculus (IFOF); and in the right hemisphere: in the visual cortex, forceps major, body of the corpus callosum (posterior parts) and inferior parietal cortex. Compared to patients without current hallucinations, patients with hallucinations revealed decreased fractional anisotropy in the left IFOF, uncinate fasciculus, arcuate fasciculus with SLF, corpus callosum (posterior parts-forceps major), cingulate, corticospinal tract and ATR. The severity of hallucinations correlated negatively with white matter integrity in tracts connecting the left frontal lobe with temporal regions (uncinate fasciculus, IFOF, cingulum, arcuate fasciculus anterior and long part and superior long fasciculus frontal part) and in interhemispheric connections (anterior corona radiata). These findings support the hypothesis that hallucinations in schizophrenia are accompanied by a complex pattern of white matter alterations that negatively affect the language, emotion and attention/perception networks. Springer-Verlag Berlin Heidelberg, 2013 Hallucinations nationallicence Anatomical connectivity nationallicence Diffusion tensor imaging (DTI) nationallicence Language network nationallicence Thalamo-cortical connectivity nationallicence Fronto-temporal connectivity nationallicence ACC : Anterior cingulate cortex nationallicence ACR : Anterior corona radiata nationallicence AF : Anterior fasciculus nationallicence ATR : Anterior thalamic radiation nationallicence AVH : Auditory verbal hallucinations nationallicence DTI : Diffusion tensor imaging nationallicence IFG : Inferior frontal gyrus nationallicence IFOF : Inferior fronto-occipital fasciculus nationallicence ILF : Inferior longitudinal fasciculus nationallicence FA : Fractional anisotropy nationallicence ROI : Region of interest nationallicence SLF : Superior longitudinal fasciculus nationallicence TBSS : Tract-based spatial statistics nationallicence TFCE : Threshold-free cluster enhancement nationallicence UF : Uncinate fasciculus nationallicence Ćurčić-Blake Branislava Department of Neuroscience, Neuroimaging Center (NIC), University Medical Center Groningen, University of Groningen, A. Deusinglaan 2, 9713AW, Groningen, The Netherlands aut Nanetti Luca Department of Neuroscience, Neuroimaging Center (NIC), University Medical Center Groningen, University of Groningen, A. Deusinglaan 2, 9713AW, Groningen, The Netherlands aut van der Meer Lisette Department of Neuroscience, Neuroimaging Center (NIC), University Medical Center Groningen, University of Groningen, A. Deusinglaan 2, 9713AW, Groningen, The Netherlands aut Cerliani Leonardo Department of Neuroscience, Neuroimaging Center (NIC), University Medical Center Groningen, University of Groningen, A. Deusinglaan 2, 9713AW, Groningen, The Netherlands aut Renken Remco Department of Neuroscience, Neuroimaging Center (NIC), University Medical Center Groningen, University of Groningen, A. Deusinglaan 2, 9713AW, Groningen, The Netherlands aut Pijnenborg Gerdina Department of Neuroscience, Neuroimaging Center (NIC), University Medical Center Groningen, University of Groningen, A. Deusinglaan 2, 9713AW, Groningen, The Netherlands aut Aleman André Department of Neuroscience, Neuroimaging Center (NIC), University Medical Center Groningen, University of Groningen, A. Deusinglaan 2, 9713AW, Groningen, The Netherlands aut Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 407-418 1863-2653 220:1<407 2015 220 429 https://doi.org/10.1007/s00429-013-0663-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-013-0663-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ćurčić-Blake Branislava Department of Neuroscience, Neuroimaging Center (NIC), University Medical Center Groningen, University of Groningen, A. Deusinglaan 2, 9713AW, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Nanetti Luca Department of Neuroscience, Neuroimaging Center (NIC), University Medical Center Groningen, University of Groningen, A. Deusinglaan 2, 9713AW, Groningen, The Netherlands aut NATIONALLICENCE 700 1- van der Meer Lisette Department of Neuroscience, Neuroimaging Center (NIC), University Medical Center Groningen, University of Groningen, A. Deusinglaan 2, 9713AW, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Cerliani Leonardo Department of Neuroscience, Neuroimaging Center (NIC), University Medical Center Groningen, University of Groningen, A. Deusinglaan 2, 9713AW, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Renken Remco Department of Neuroscience, Neuroimaging Center (NIC), University Medical Center Groningen, University of Groningen, A. Deusinglaan 2, 9713AW, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Pijnenborg Gerdina Department of Neuroscience, Neuroimaging Center (NIC), University Medical Center Groningen, University of Groningen, A. Deusinglaan 2, 9713AW, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Aleman André Department of Neuroscience, Neuroimaging Center (NIC), University Medical Center Groningen, University of Groningen, A. Deusinglaan 2, 9713AW, Groningen, The Netherlands aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 407-418 1863-2653 220:1<407 2015 220 429