caa a22 4500 606201130 CHVBK 20210128100946.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00429-013-0640-5 doi (NATIONALLICENCE)springer-10.1007/s00429-013-0640-5 DISC1 Ser704Cys impacts thalamic-prefrontal connectivity [Elektronische Daten] [Bing Liu, Lingzhong Fan, Yue Cui, Xiaolong Zhang, Bing Hou, Yonghui Li, Wen Qin, Dawei Wang, Chunshui Yu, Tianzi Jiang] The Disrupted-in-Schizophrenia 1 (DISC1) gene has been thought as a putative susceptibility gene for various psychiatric disorders, and DISC1 Ser704Cys is associated with variations of brain morphology and function. Moreover, our recent diffusion magnetic resonance imaging (dMRI) study reported that DISC1 Ser704Cys was associated with information transfer efficiency in the brain anatomical network. However, the effects of the DISC1 gene on functional brain connectivity and networks, especially for thalamic-prefrontal circuit, which are disrupted in various psychiatric disorders, are largely unknown. Using a functional connectivity density (FCD) mapping method based on functional magnetic resonance imaging data in a large sample of healthy Han Chinese subjects, we first investigated the association between DISC1 Ser704Cys and short- and long-range FCD hubs. Compared with Ser homozygotes, Cys-allele individuals had increased long-range FCD hubs in the bilateral thalami. The functional and anatomical connectivity of the thalamus to the prefrontal cortex was further analyzed. Significantly increased thalamic-prefrontal functional connectivity and decreased thalamic-prefrontal anatomical connectivity were found in DISC1 Cys-allele carriers. Our findings provide consistent evidence that the DISC1 Ser704Cys polymorphism influences the thalamic-prefrontal circuits in humans and may provide new insights into the neural mechanisms that link DISC1 and the risk for psychiatric disorders. The Author(s), 2013 DISC1 nationallicence Functional connectivity density nationallicence Anatomical connectivity nationallicence Thalamus nationallicence Thalamic-prefrontal circuit nationallicence Liu Bing Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, 100190, Beijing, China aut Fan Lingzhong Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, 100190, Beijing, China aut Cui Yue Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, 100190, Beijing, China aut Zhang Xiaolong Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, 100190, Beijing, China aut Hou Bing Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, 100190, Beijing, China aut Li Yonghui Queensland Brain Institute, The University of Queensland, 4072, Brisbane, QLD, Australia aut Qin Wen Department of Radiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, 300052, Tianjin, China aut Wang Dawei Department of Radiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, 300052, Tianjin, China aut Yu Chunshui Department of Radiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, 300052, Tianjin, China aut Jiang Tianzi Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, 100190, Beijing, China aut Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 91-100 1863-2653 220:1<91 2015 220 429 https://doi.org/10.1007/s00429-013-0640-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-013-0640-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu Bing Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, 100190, Beijing, China aut NATIONALLICENCE 700 1- Fan Lingzhong Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, 100190, Beijing, China aut NATIONALLICENCE 700 1- Cui Yue Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, 100190, Beijing, China aut NATIONALLICENCE 700 1- Zhang Xiaolong Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, 100190, Beijing, China aut NATIONALLICENCE 700 1- Hou Bing Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, 100190, Beijing, China aut NATIONALLICENCE 700 1- Li Yonghui Queensland Brain Institute, The University of Queensland, 4072, Brisbane, QLD, Australia aut NATIONALLICENCE 700 1- Qin Wen Department of Radiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, 300052, Tianjin, China aut NATIONALLICENCE 700 1- Wang Dawei Department of Radiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, 300052, Tianjin, China aut NATIONALLICENCE 700 1- Yu Chunshui Department of Radiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, 300052, Tianjin, China aut NATIONALLICENCE 700 1- Jiang Tianzi Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, 100190, Beijing, China aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/1(2015-01-01), 91-100 1863-2653 220:1<91 2015 220 429